Q.Give an account of mechanism of vision. OR Describe various disorders of digestive system.

Mechanism of Vision: How Your Eye Turns Light Into Sight

Think of your eye as a biological camera that doesn't just capture an image — it has to translate that image into a language your brain can understand. The camera part (lens, pupil, cornea) focuses light onto the back of your eye. But the real magic happens in the retina, where light energy gets converted into electrical signals your brain reads as vision.

The key player in this conversion is a light-sensitive molecule called rhodopsin, found in the rod cells of the retina. Without rhodopsin, no amount of focused light would ever become a nerve impulse.

The Photochemical Change: What Happens When Light Hits Rhodopsin

Rhodopsin is a complex molecule made of two parts: a protein called opsin and a light-absorbing pigment called retinal (a derivative of vitamin A). In the dark, retinal is in a bent shape called 11-cis-retinal, and it sits snugly inside opsin.

When a photon of light strikes rhodopsin, the 11-cis-retinal absorbs the energy and instantly straightens out into all-trans-retinal. This shape change is the trigger — it forces opsin to change its own shape, activating it.

The activated opsin then sets off a chain reaction inside the rod cell. It activates a G-protein called transducin, which in turn activates an enzyme that breaks down cGMP (cyclic guanosine monophosphate). In the dark, cGMP keeps sodium channels open, maintaining the cell in a depolarised state. When cGMP levels drop, those channels close, the cell hyperpolarises, and this change in voltage triggers the release of neurotransmitter at the synapse with the bipolar cell.

That neurotransmitter release is the nerve impulse — the signal that travels along the optic nerve to the brain.

The Big Picture: From Photon to Perception

Here is the sequence in one clean flow:

1. Light enters the eye and is focused on the retina.
2. Rhodopsin absorbs a photon — 11-cis-retinal isomerises to all-trans-retinal.
3. Opsin activates transducin, which activates phosphodiesterase.
4. cGMP is broken down, sodium channels close.
5. Rod cell hyperpolarises, reducing neurotransmitter release.
6. Bipolar cell and ganglion cell detect the change and fire an action potential.
7. Optic nerve carries the signal to the visual cortex of the brain.

Why This Matters for Exams

You will often be asked to explain the photochemical change in rhodopsin and how it leads to a nerve impulse. The critical points are:

• The isomerisation of retinal (cis → trans) is the only direct effect of light.
• This triggers a G-protein cascade that amplifies the signal — one photon can close hundreds of sodium channels. …