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Q.What are Microglia and what is their origin and add a note on their function?

Telangana TsbieTelangana Board of Intermediate Education (Intermediate 1st Year) 2019Subjective· 2mImportance★★★★★
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Microglia are the CNS's own immune/scavenger cells — mesoderm-derived phagocytes, distinct in origin from the ectodermal astrocytes and oligodendrocytes, that defend nervous tissue and clear debris.

Origin:

Most neuroglial cells (astrocytes, oligodendrocytes, ependymal cells) arise from the same neuroectoderm as neurons. Microglia are the exception — they are mesodermal in origin, arising from monocytes/macrophage precursor cells that migrate into and colonise the developing central nervous system.

Structure:

Microglia are small cells with an elongated nucleus and relatively few, branching (ramified) processes compared to astrocytes. They are distributed throughout the grey and white matter of the brain and spinal cord.

Function:

  • They act as the resident macrophages/immune cells of the CNS, since the CNS is largely isolated from the general circulating immune system by the blood–brain barrier.
  • They phagocytose invading microorganisms, damaged or dead neural cells, and cellular debris resulting from injury or degeneration. …

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