Q.Write a short note on Transportation of gases in human beings.
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Start your 14-day free trial to unlock the full solution →O2 travels mainly as oxyhaemoglobin; CO2 travels mainly as plasma bicarbonate, with smaller amounts as carbamino-haemoglobin and dissolved gas.
Transport of Oxygen:
Haemoglobin (Hb) in red blood cells is the principal carrier of oxygen. In the lungs, where pO2 is high, Hb binds O2 to form oxyhaemoglobin (Hb + 4O2 ⇌ HbO8, i.e. HbO2 per subunit); in the tissues, where pO2 is low and pCO2/H+ are higher, oxyhaemoglobin dissociates and releases O2 to the tissues (Bohr effect). About 97% of O2 is carried this way; the remaining ~3% is simply dissolved in blood plasma.
Transport of Carbon Dioxide:
CO2 produced by tissues is transported in three forms:
- As bicarbonate (HCO3⁻), ~70%: CO2 diffuses into RBCs, where the enzyme carbonic anhydrase rapidly catalyses CO2 + H2O → H2CO3 → H+ + HCO3⁻. The HCO3⁻ diffuses out into the plasma (exchanged for Cl⁻ from plasma — the 'chloride shift'), while H+ is buffered by haemoglobin. …
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