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NCERT Exemplar · Q4

Q.α-1 antitrypsin is:

(a) An antacid
(b) An enzyme
(c) Used to treat arthritis
(d) Used to treat emphysema
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Alpha-1 antitrypsin is a therapeutic protein produced using biotechnology, specifically in transgenic animals, and is used to treat the lung condition emphysema.

The advent of biotechnology has revolutionized the production of various therapeutic proteins, offering solutions for diseases that were previously difficult to manage. One of the key applications involves genetically engineering organisms to produce specific proteins that can be used as medicines. This process typically involves isolating the gene responsible for producing a desired protein and introducing it into a host organism, which then expresses the gene and synthesizes the protein.

While bacteria are often used as hosts for producing proteins like insulin, other complex proteins or those requiring specific post-translational modifications are sometimes produced in higher organisms. This leads us to the concept of transgenic animals – animals that have had their DNA modified by the introduction of a foreign gene. These transgenic animals can then serve as "bioreactors" to produce valuable biological products.

Important

The NCERT textbook specifically highlights transgenic animals as the source for producing proteins like alpha-1 antitrypsin.

Alpha-1 antitrypsin is one such therapeutic protein. It is naturally present in the human body and plays a crucial role in protecting the lungs from damage caused by enzymes, particularly elastase, which can break down connective tissues. A deficiency in alpha-1 antitrypsin can lead to a severe lung condition. …

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