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Exercise · Q3

Q._____________ cell junction is mediated by integrin.

(a) Gap
(b) Hemidesmosomes
(c) Desmosomes
(d) Adherens
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✓ Free question

Step 1. Of the five cell junctions, gap junctions form channel-like pores for ion/molecule passage, desmosomes give mechanical strength between adjoining cells, and adherens junctions take part in cell signalling — none of these is specifically the integrin-mediated junction.

Step 2. Hemidesmosomes are the junctions that let a cell strongly adhere to the basement membrane beneath it (rather than to a neighbouring cell), and this attachment is mediated by transmembrane integrin proteins linking the cell's cytoskeleton to the basement-membrane matrix.

Step 3. This integrin-based link is also what allows hemidesmosomes to maintain tissue homeostasis through signalling, as the chapter describes.

✓Final answer

(b) Hemidesmosomes

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