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NCERT Exemplar · Q18

Q.Mother and father of a person with 'O' blood group have 'A' and 'B' blood group, respectively. What would be the genotype of both mother and father?

(a) Mother is homozygous for 'A' blood group and father is heterozygous for 'B'
(b) Mother is heterozygous for 'A' blood group and father is homozygous for 'B'
(c) Both mother and father are heterozygous for 'A' and 'B' blood group, respectively
(d) Both mother and father are homozygous for 'A' and 'B' blood group, respectively
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A child with O blood group must inherit one recessive i allele from each parent, so both parents must carry that allele — meaning the mother with A blood group is heterozygous (IAi) and the father with B blood group is heterozygous (IBi).

To understand this, we need to revisit the basics of ABO blood group inheritance as taught in NCERT. The ABO system is controlled by a single gene on chromosome 9, which has three alleles: IA, IB, and i. Both IA and IB are dominant over i, but they are codominant with each other — meaning if a person inherits both IA and IB, they express both and have AB blood group.

The possible genotypes and corresponding blood groups are:

  • IAIA or IAi → A blood group
  • IBIB or IBi → B blood group
  • IAIB → AB blood group
  • ii → O blood group

Now, the child in this question has O blood group. That means the child’s genotype must be ii — two recessive i alleles, one inherited from each parent. This is the crucial point: since the child has no dominant allele from either parent, each parent must have contributed an i allele.

The mother has A blood group. She could be either IAIA (homozygous) or IAi (heterozygous). But because she passed an i allele to her child, she cannot be IAIA — that genotype has no i allele to give. So the mother must be IAi, i.e., heterozygous for A.

Similarly, the father has B blood group. He could be IBIB or IBi. Since he also passed an i allele to the child, he cannot be IBIB. So the father must be IBi, i.e., heterozygous for B.

Note

This is a classic example of how a recessive trait (O blood group) can appear in a child even when both parents show dominant phenotypes (A and B). The key is that both parents are carriers of the recessive i allele.

Now let’s look at the options given: …

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