Q.Name the only hormone secreted by pars intermedia of the pituitary gland.
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The Master Gland and Its Messengers
The pituitary gland sits at the base of your brain, about the size of a pea. But don't let its size fool you — it's called the "master gland" because it controls so many other glands in your body. Think of it as the CEO of a company: it doesn't do all the work itself, but it sends out orders that make other departments (thyroid, adrenal glands, ovaries, testes) do their jobs.
The pituitary has two distinct parts: the anterior lobe (front) and the posterior lobe (back). They're like two different departments that happen to share the same building. The anterior lobe makes its own hormones; the posterior lobe stores and releases hormones that were actually made in the brain (the hypothalamus).
Anterior Pituitary Hormones (Made Here)
The anterior pituitary produces six major hormones. Each one targets a specific organ or tissue elsewhere in the body.
Growth Hormone (GH)
GH stimulates growth in almost every tissue — especially bones and muscles. It's most active during childhood and adolescence. If too little is secreted, a child may have stunted growth (pituitary dwarfism). Too much can lead to gigantism in children or acromegaly (enlarged hands, feet, jaw) in adults.
Thyroid-Stimulating Hormone (TSH)
TSH travels to the thyroid gland in your neck and tells it to release thyroid hormones (T3 and T4). Those thyroid hormones then regulate your metabolism — how fast your body burns energy. Without TSH, your thyroid goes dormant.
Adrenocorticotropic Hormone (ACTH)
ACTH targets the adrenal cortex (the outer layer of the adrenal glands, which sit on top of your kidneys). It triggers the release of cortisol, a stress hormone that helps manage blood sugar, inflammation, and immune responses.
Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH)
These two work together as the gonadotropins — they control the reproductive system.
- In females: FSH stimulates the growth of ovarian follicles (which contain eggs); LH triggers ovulation (release of the egg) and helps form the corpus luteum.
- In males: FSH helps produce sperm; LH stimulates testosterone production from the testes.
Prolactin
Prolactin's main job is to initiate and maintain milk production in the mammary glands after childbirth. It's normally kept in check by dopamine from the hypothalamus — that's why prolactin levels stay low unless a woman is breastfeeding.
The anterior pituitary is sometimes called the adenohypophysis. Its hormones are all protein or peptide hormones — they can't cross cell membranes, so they bind to surface receptors and trigger second messengers inside the cell.
Posterior Pituitary Hormones (Stored Here, Made Upstairs)
The posterior pituitary doesn't make its own hormones. Instead, the hypothalamus (the brain region just above it) produces two hormones, which then travel down nerve fibres into the posterior pituitary for storage and release.
Oxytocin
Oxytocin is best known for two actions:
- Childbirth: It stimulates strong contractions of the uterine muscles during labour.
- Milk ejection: When a baby suckles, oxytocin is released, causing milk to be "let down" from the mammary glands.
It's also involved in bonding and social behaviour — sometimes called the "love hormone."
Vasopressin (Antidiuretic Hormone, ADH)
Vasopressin acts on the kidneys. It tells them to reabsorb more water back into the blood, producing more concentrated urine. This is how your body conserves water when you're dehydrated.
If vasopressin is deficient, you get diabetes insipidus — not the sugar-related diabetes, but a condition where you produce huge volumes of dilute urine and feel constantly thirsty.
Don't confuse diabetes insipidus (ADH deficiency) with diabetes mellitus (insulin deficiency). Both cause frequent urination, but the underlying hormones and mechanisms are completely different.
Summary Table
| Part | Hormone | Target | Main Effect |
|---|---|---|---|
| Anterior | GH | Bones, muscles, tissues | Growth |
The only hormone secreted by the pars intermedia is melanocyte stimulating hormone (MSH).
- The pars intermedia is a part of the adenohypophysis, though in humans it is almost fused with the pars distalis (anterior pituitary).
- It secretes just this one hormone. …
The pars intermedia of the pituitary secretes just one hormone, melanocyte stimulating hormone, which regulates skin pigmentation.
The pituitary gland's adenohypophysis is made of two portions: the pars distalis, commonly called the anterior pituitary, and the pars intermedia. While the pars distalis is a busy hormone factory producing six different hormones, the pars intermedia is comparatively simple in output, secreting only a single hormone, melanocyte stimulating hormone (MSH). …
- Council of Higher Secondary Education, Manipur (Higher Secondary 1st Year) 2024Set ANNUAL1 markQ.“Vasopressin is also known as antidiuretic hormone”. Comment.
›Reveal solutionSolution
Vasopressin promotes water reabsorption in the kidney, concentrating urine and reducing its volume — the exact opposite of diuresis — which is why it is named the antidiuretic hormone.
Vasopressin is synthesised by the hypothalamus and released from the posterior pituitary (neurohypophysis). Its principal target is the kidney nephron, where it:
- Increases the permeability to water of the distal convoluted tubule (DCT) and the collecting duct.
- This allows more water to be reabsorbed back into the blood from the filtrate as it passes through these regions, instead of being excreted.
- The result is a smaller volume of more concentrated urine, i.e., water loss from the body is minimised. …
- Council of Higher Secondary Education, Manipur (Higher Secondary 1st Year) 2021Set ANNUAL1 markMCQQ.With reference to pituitary gland, which one of the following is true ?(a) Neurohypophysis secretes TSH and STH(b) Neurohypophysis secretes MSH(c) Adenohypophysis secretes Vasopressin and Oxytocin(d) Pars intermedia secretes MSH
›Reveal solutionSolution
Pars intermedia, a division of the adenohypophysis, secretes MSH; TSH and STH come from pars distalis (not neurohypophysis), and oxytocin/vasopressin are released by the neurohypophysis (not adenohypophysis) though made in the hypothalamus.
The pituitary (hypophysis) has two main regions: the adenohypophysis (anterior pituitary), itself divided into pars distalis and pars intermedia, and the neurohypophysis (posterior pituitary). Pars distalis secretes growth hormone (STH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), and the gonadotropins (LH, FSH), along with prolactin — so option (a), which credits these to the neurohypophysis, is wrong. Pars intermedia secretes melanocyte-stimulating hormone (MSH), which regulates melanocyte pigmentation — this makes option ( …
- Council of Higher Secondary Education, Manipur (Higher Secondary 1st Year) 2021Set ANNUAL1 markQ.Why is oxytocin called birth hormone ?
›Reveal solutionSolution
Oxytocin earns the name 'birth hormone' because it causes the uterine muscle contractions that drive labour and delivery.
Oxytocin is a hormone synthesised in the hypothalamus and released from the posterior pituitary (neurohypophysis). Near the end of pregnancy, the uterus becomes highly sensitive to oxytocin. As labour begins, rising oxytocin levels stimulate the smooth muscle of the uterine wall (myometrium) to undergo strong, rhythmic contractions. These contractions push the foetus through the birth canal during delivery. This surge of contractions triggered by oxytocin is central to the process of parturition, which is why oxytocin is popularly call …
- Council of Higher Secondary Education, Manipur (Higher Secondary 1st Year) 2021Set ANNUAL1 markQ."Vasopressin is also known as antidiuretic hormone". Comment.
›Reveal solutionSolution
Vasopressin is called ADH because it makes the kidneys reabsorb more water, producing less, more concentrated urine and helping the body conserve water.
Vasopressin is synthesised by neurosecretory cells of the hypothalamus and released into the blood from the posterior pituitary (neurohypophysis). Its principal target is the kidney, specifically the distal convoluted tubule and collecting duct of the nephron, where it increases the permeability of these tubules to water. This promotes greater reabsorption of water from the filtrate back into the blood, which concentrates the urine and reduces the total volume excreted. When body fluid is low or blood osmotic pressure rises (e.g., during dehydration), vasopressin secretion increases to conserve water; when the body is well-hydrated, its secretion decreases …
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