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NCERT Exemplar · Q24

Q.Certain pathogens are tissue/organ specific. Justify the statement with suitable examples.

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Pathogens exhibit tissue or organ specificity because they possess surface molecules that bind to complementary receptors found only on certain host cells, and they require the unique biochemical environment of particular tissues to survive and multiply.

When a pathogen enters the body, it doesn't simply attack every cell it encounters. Instead, most disease-causing microorganisms show a remarkable preference for particular tissues or organs. This specificity isn't random — it arises from the precise molecular compatibility between the pathogen's surface proteins and the receptors present on host cells, combined with the pathogen's metabolic requirements.

Think of it as a lock-and-key mechanism. A pathogen can only invade and establish infection in cells that display the right "lock" (receptor) for its "key" (surface attachment proteins). Beyond mere attachment, the pathogen must also find the internal environment of that tissue hospitable — the right pH, temperature, nutrients, and oxygen levels to sustain its growth and reproduction.

The malaria parasite Plasmodium provides a striking example. After being injected by a mosquito, the parasite first travels to the liver, where it infects hepatocytes (liver cells). Here it multiplies rapidly. But the parasite doesn't remain in the liver; it then targets red blood cells specifically, invading them and reproducing inside. The parasite cannot infect muscle cells, nerve cells, or kidney cells because those lack the specific surface receptors and internal conditions Plasmodium requires. The cyclical fever characteristic of malaria corresponds to the synchronized rupture of infected RBCs.

Similarly, the bacterium Streptococcus pneumoniae and the Haemophilus influenzae bacterium show a strong preference for the lungs. They attach to the epithelial cells lining the respiratory tract and alveoli, causing pneumonia. These bacteria don't typically infect the intestines or urinary tract because the cellular receptors and environmental conditions there don't support their colonization.

Note

The common cold and influenza viruses also demonstrate respiratory tissue specificity. They bind to receptors on the mucous membranes of the nose, throat, and upper respiratory passages, which is why symptoms are localized to those areas.

The typhoid bacterium Salmonella typhi targets the small intestine initially, but then spreads to other organs. However, its primary site of action remains the intestinal lymphoid tissue (Peyer's patches), where it multiplies and causes the characteristic symptoms of enteric fever. …

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