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NCERT Exemplar · Q35

Q.Can a child have blood group O if his parents have blood group 'A' and 'B'. Explain.

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Yes, a child can have blood group O if both parents (one A, one B) are heterozygous carriers of the recessive O allele.

The ABO blood group system is one of the clearest examples of multiple allelism and codominance in human genetics. Three alleles govern blood type: $I^A$, $I^B$, and $i$. The first two are codominant to each other but both are completely dominant over $i$, which is recessive. A person with blood group A can have the genotype $I^A I^A$ (homozygous) or $I^A i$ (heterozygous). Similarly, blood group B can be $I^B I^B$ or $I^B i$. Blood group O appears only when both alleles are recessive: $ii$.

Now consider the scenario in the question. If one parent has blood group A and the other has blood group B, we need to examine their possible genotypes. The parent with blood group A could be either $I^A I^A$ or $I^A i$, and the parent with blood group B could be either $I^B I^B$ or $I^B i$. For a child to have blood group O, the child must inherit an $i$ allele from each parent — the only way to produce the $ii$ genotype.

This is possible if and only if both parents are heterozygous carriers. When the A parent is $I^A i$ and the B parent is $I^B i$, each can pass on either their dominant allele or the recessive $i$ allele to their offspring. A Punnett square for this cross shows four possible combinations:

  • $I^A I^B$ → blood group AB (codominance expressed)
  • $I^A i$ → blood group A
  • $I^B i$ → blood group B
  • $ii$ → blood group O …

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