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Question 28 of 29

Q.Who discovered Prions?

(a) T.O. Diener
(b) J.W. Randles
(c) R.H. Whittaker
(d) Stanley B. Prusiner
Puducherry TnboardTamil Nadu HSC First Year (DGE) Board 2026MCQ· 1mImportance★★★★★
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Prions, infectious protein-only particles with no nucleic acid, were discovered by Stanley B. Prusiner.

When classifying life forms, biologists encounter a few entities that blur the line between living and non-living. Viruses have nucleic acid wrapped in protein; viroids (discovered by T.O. Diener) are even simpler — free RNA with no protein coat. Prions go a step further: they are purely proteinaceous infectious particles with NO nucleic acid at all. A prion is a misfolded version of a normal cellular protein; on contact, it converts the normal protein into the same misfolded, disease-causing form, allowing the abnormality to 'spread' without any genetic material being involved. This unusual mechanism causes neurodegenerative diseases such as scrapie in sheep, mad cow disease (BSE), and Creutzfeldt-Jakob disease in humans. Stanley B. Prusiner proposed and established this protein-only in …

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