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Q.What is sarcopenia? State any one reason why it occurs with ageing.

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Sarcopenia is a progressive, age-related loss of skeletal muscle mass, strength, and function, often occurring due to hormonal changes and reduced physical activity.

Sarcopenia is a significant health concern, particularly in older adults, that directly impacts physical performance and quality of life. The term "sarcopenia" originates from Greek words: "sarx" meaning flesh, and "penia" meaning loss. It describes a condition characterized by the progressive and generalized loss of skeletal muscle mass, muscle strength, and physical performance.

This condition is not merely a cosmetic change; it has profound functional consequences. Individuals with sarcopenia experience reduced ability to perform daily activities, an increased risk of falls and fractures, and a higher likelihood of frailty and loss of independence. It can also worsen the prognosis of various chronic diseases.

One primary reason why sarcopenia occurs with ageing is hormonal changes. As individuals age, there is a natural decline in the levels of several hormones that are crucial for maintaining muscle mass and strength.

  • Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1): These hormones play a vital role in stimulating muscle protein synthesis and promoting muscle growth. With age, the production and sensitivity to GH and IGF-1 decrease, leading to a reduced capacity for muscle repair and regeneration. …

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