Q.Which of the phases of cell cycle is of longest duration?
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The Cell Cycle: Why Cells Need a Schedule
Think of a cell as a tiny factory that has to make an exact copy of itself — every protein, every organelle, every strand of DNA. You can't just split in half randomly; that would be chaos. The cell follows a strict, ordered sequence called the cell cycle, which ensures that before a cell divides, it has first made a perfect duplicate of its entire genome and enough cellular machinery to support two daughter cells.
The entire cycle is divided into two broad phases: Interphase (the preparation phase) and M phase (the division phase). Interphase is long — typically 90% of the cycle — because copying everything takes time. M phase is short and dramatic.
Interphase: The Quiet Workhorse
Interphase is often mistakenly called the "resting phase." It is anything but restful. The cell is metabolically active, growing, and duplicating its DNA. Interphase is subdivided into three stages:
G1 phase (Gap 1) — The cell grows physically, synthesizes proteins, and produces organelles. It's also a checkpoint: if conditions are unfavourable (no nutrients, DNA damage), the cell may exit into a non-dividing state called G0. Most cells in your body are in G0.
S phase (Synthesis) — This is the critical moment: DNA replication. Each chromosome goes from one chromatid to two identical sister chromatids, held together at the centromere. By the end of S phase, the cell has twice the normal amount of DNA.
G2 phase (Gap 2) — The cell continues to grow and produces the proteins needed for division (like tubulin for spindle fibres). Another checkpoint verifies that DNA replication was complete and error-free.
The genome is duplicated only during S phase. The cell does not divide until it has two complete copies of every chromosome.
M Phase: The Visible Drama
M phase is where the cell actually divides. It has two parts:
Mitosis — The nucleus divides. The duplicated chromosomes are separated equally into two daughter nuclei. Mitosis itself has four stages (prophase, metaphase, anaphase, telophase) that you will study in detail.
Cytokinesis — The cytoplasm divides, splitting the cell into two separate daughter cells. In animal cells, a cleavage furrow pinches the cell in half; in plant cells, a cell plate forms.
The Complete Picture
The cell cycle is usually written as:
G1→S→G2→M→Cytokinesis …
Among all the phases that make up a full cell cycle, one single stretch accounts for the overwhelming majority of the total time.
- The cell cycle is split into two fundamental phases: interphase and the M phase (mitosis).
- Although the M phase is the most visible and dramatic event, it occupies only a small slice of time — in a 24-hour human cell cycle, division itself lasts only about an hour. …
Interphase, not the M phase, occupies the overwhelming majority of the cell cycle — more than 95 per cent of the total time in a typical human cell.
A convenient way to see this is to look at a typical eukaryotic cell cycle, such as that of human cells grown in culture, which divide roughly once every 24 hours. Within that 24-hour span, the cell cycle breaks down into two fundamental phases:
- Interphase — the period between two successive divisions, itself made up of the G1, S and G2 sub-phases, during which the cell grows continuously and carefully replicates its DNA.
- M Phase (mitosis) — the comparatively brief stage where the actual division of the nucleus and cytoplasm takes place. …
Method: Compare interphase to M phase durations
- Recall the cell cycle's two broad divisions: interphase (G1+S+G2) and M phase.
- Recall a concrete example: human cells cycle ~24 h, of which M phase is only ~1 h. …
- AP EAPCET 2026Set ap-2026-05-19-FN1 markMCQQ.Match the following lists List-I | List-II I. Centriole undergo duplication | A. Prophase II. Initiation and assembly of mitotic spindles | B. Quiescent III. Cells are metabolically active but without division | C. Mitosis metaphase IV. Chromosomes move to equator | D. S-Phase (A) I-D, II-B, III-A, IV-C (B) I-D, II-A, III-B, IV-C (C) I-D, II-C, III-B, IV-A (D) I-C, II-A, III-B, IV-D
›Reveal solutionSolution
Matches four cell-cycle events to their phase: centriole duplication (S phase), spindle assembly (prophase), metabolically-active-but-non-dividing cells (G0/quiescent), and chromosome movement to the equator (metaphase).
Concept and Intuition
The cell cycle is divided into interphase (G1 → S → G2, where the cell grows and replicates its DNA/organelles) and the mitotic (M) phase (itself divided into prophase, metaphase, anaphase, telophase, where the replicated chromosomes are actually segregated). Some cells exit the cycle altogether into G0 (quiescent), remaining alive and functional without dividing.
Step-by-Step Solution
- I: Centrioles duplicate once per cell cycle, in step with DNA replication, during S phase. Match: D.
- II: The mitotic spindle apparatus begins forming as chromatin condenses into visible chromosomes, at the start of prophase. Match: A.
- III: Cells that remain metabolically active (protein synthesis, normal function) but do not proceed further through the cycle are said to be in the quiescent (G0) stage. Match: B. …
- AP EAPCET 2025Set ap-2025-05-19-AN1 markMCQQ.Choose the correct statements among the following I. Duplication of genome, synthesis of other constituent of cell and division to produce new cells is called cell cycle. II. Interphase is followed by resting phase. III. In every cell division, genetic variability will increase from generation to generation. IV. Plant cells can divide mitotically in both haploid and diploid cells. (A) I, II (B) III, IV (C) I, IV (D) II, IV
›Reveal solutionSolution
Statements I and IV are correct (cell-cycle definition; plant mitosis in both haploid and diploid phases); II and III are wrong, giving option (C).
Concept and Intuition
This question probes precise understanding of the cell cycle versus common misconceptions about resting phases and genetic variability.
Step-by-Step Solution
- I. The cell cycle is indeed defined as the sequence of events (DNA duplication, synthesis of other cellular constituents, and division) that produces two daughter cells from one. True.
- II. It is the G1 phase (part of interphase) from which a non-dividing cell exits into the quiescent G0 ('resting') stage — it is not that 'interphase is followed by' a separate resting phase. False as stated.
- III. Genetic variability increases specifically through meiosis (recombination, independent assortment) associated with sexual reproduction — ordinary mitotic cell divisions produce genetically identical daughter cells, so variability does not increase 'in every cell division'. False. …
- AP EAPCET 2024Set ap-2024-05-16-AN1 markMCQQ.Number of chromosomes in maize root cells at G1 phase, after S and M phases respectively (A) 20, 20, 20 (B) 20, 40, 20 (C) 20, 10, 20 (D) 40, 20, 20
›Reveal solutionSolution
Chromosome number is invariant through G1, S, and after M in maize (2n=20); only DNA content/chromatid count changes during S phase.
Concept and Intuition
A common misconception is that DNA replication (S phase) doubles the chromosome number. It does not - replication converts each single-chromatid chromosome into a two-chromatid chromosome (sister chromatids joined at the centromere), doubling the DNA content (2C to 4C) but not the chromosome count, since the two chromatids are still counted as one chromosome until they separate at anaphase of mitosis. Only after anaphase, when sister chromatids separate and move to opposite poles, does each resulting daughter nucleus revert to the original chromosome number with 2C DNA content.
Step-by-Step Solution
- Maize root cell (somatic, diploid) has 2n=20 chromosomes.
- At G1: chromosome number = 20 (2C DNA, single-chromatid chromosomes).
- After S phase: chromosome number is still 20 (now 4C DNA, each chromosome has 2 sister chromatids), because replication doesn't create new chromosomes, it duplicates the DNA within each. …
- AP EAPCET 2021Set ap-2021-09-06-FN1 markMCQQ.Select the incorrect statement of cell cycle? (A) The cell is metabolically active (B) The amount of DNA per cell doubles (C) The number of chromosomes remains the same (D) The interphase lasts less than 95% of the duration of cell cycle
›Reveal solutionSolution
The false statement is (D) — interphase actually occupies more (not less) than 95% of the cell cycle; the other three statements about interphase/mitosis are correct.
Concept and Intuition
The cell cycle consists of interphase (G1, S, G2 — growth, DNA replication, preparation) followed by the much shorter M phase (mitosis/division). Interphase is when the cell is metabolically very active, DNA content doubles during S phase (while chromosome NUMBER stays the same, since sister chromatids remain joined until anaphase), and interphase dominates the cycle's total duration overwhelmingly.
Step-by-Step Solution
- (A) the cell is metabolically active during interphase — TRUE.
- (B) DNA content doubles during interphase (S phase) — TRUE.
- (C) chromosome number stays the same throughout interphase (replication doesn't change chromosome count until sister chromatids separate at anaphase) — TRUE. …
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