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Q.(a) State the mode of action of cocain on human body. Write the scientific name of the source plant it is obtained from.

(OR)
(b) Enumerate four most common warning signs of drug and alcohol abuse amongst the youth.
CBSECBSE Class XII Board 2022Subjective· 2mImportance★★★★★
✓ Free question

Part (a): Cocaine blocks dopamine re-uptake at synapses, so dopamine accumulates and over-stimulates the CNS (euphoria); it is obtained from Erythroxylum coca.

Part (b): Warning signs of youth drug/alcohol abuse include falling grades/absenteeism, social withdrawal and poor hygiene, disturbed sleep and appetite, and aggressive/depressed behaviour.


Mode of action of cocaine and its source plant

Neurons communicate by releasing chemical messengers (neurotransmitters) into the synaptic cleft. After a signal is delivered, the neurotransmitter is normally cleared by re-uptake into the pre-synaptic neuron through transporter proteins, terminating the signal.

Cocaine, obtained from the coca plant, is a powerful CNS stimulant. It acts specifically on the neurotransmitter dopamine:

  1. Cocaine binds to and blocks the dopamine transporter on the pre-synaptic membrane.
  2. With re-uptake blocked, dopamine accumulates in the synaptic cleft.
  3. The excess dopamine repeatedly stimulates the post-synaptic receptors, especially in the brain's reward pathway, producing intense euphoria, a sense of well-being and increased energy. Higher doses cause hallucinations.
  4. Repeated use leads to strong psychological dependence and addiction, and can cause serious cardiovascular effects.

Source plant: Cocaine is an alkaloid extracted from Erythroxylum coca, a plant native to South America.

✓Final answer

Cocaine acts on the CNS by blocking the re-uptake of dopamine, causing dopamine to accumulate in the synapse and over-stimulate the post-synaptic neurons (euphoria and heightened energy). It is obtained from Erythroxylum coca.


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