Question of 56
Q.Henle's loop plays an important role in concentrating the urine. How?
Kerala DhseKerala DHSE Plus One Board 2024Subjective· 2mImportance★★★★★
0% · 0/56 Questions
You're viewing a preview — the full solution, concept, methods & PYQ mapping are locked.
Start your 14-day free trial to unlock the full solution →Henle's loop, working as a countercurrent multiplier with the vasa recta, builds up a high salt concentration deep in the kidney medulla; this gradient later pulls water out of the collecting duct, producing concentrated (hypertonic) urine.
Henle's loop is a long, hairpin-shaped part of the nephron with a descending limb (permeable to water, relatively impermeable to salts) and an ascending limb (impermeable to water, but actively transports NaCl out into the surrounding interstitial tissue).
Mechanism (countercurrent multiplier):
- As the filtrate flows down the descending limb, water passively moves out into the surrounding medullary interstitium (which is already salty), so the filtrate becomes progressively more concentrated toward the tip of the loop.
- As the (now concentrated) filtrate flows up the ascending limb, NaCl is actively pumped out into the interstitium, while water cannot follow (the ascending limb is impermeable to water). This makes the filtrate more dilute as it moves up, and simultaneously keeps adding salt to the medullary interstitium.
- Because the descending and ascending limbs carry fluid in opposite directions right next to each other, this arrangement ("countercurrent") progressively multiplies and maintains a steep, increasing osmotic gradient from the cortex (less concentrated) down to the inner medulla (highly concentrated) — this is why it's called the countercurrent multiplier. …
Unlock everything free for 14 days
- Full step-by-step solutions
- Concept-first explanations
- Methods, shortcuts & mistakes
- PYQ mapping + timed mock tests
Full access for 14 days. No credit card required.