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Question 23 of 33

Q.The compound which links glycolysis and Krebs Cycle is:

(a) Acetyl CoA
(b) Succinic acid
(c) Citric acid
(d) Pyruvic acid
Puducherry TnboardTamil Nadu HSC First Year (DGE) Board 2024MCQ· 1mImportance★★★★★
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Acetyl CoA is the biochemical link between glycolysis (which ends with pyruvate) and the Krebs cycle (which begins by combining acetyl CoA with oxaloacetate).

Glycolysis, occurring in the cytoplasm, breaks down one molecule of glucose into two molecules of pyruvic acid (pyruvate), with a net gain of 2 ATP and 2 NADH. Before the carbon skeleton can enter the mitochondrial Krebs cycle, pyruvate must first be converted into a form the cycle can use.

This conversion — the link reaction — happens in the mitochondrial matrix and is catalysed by the pyruvate dehydrogenase enzyme complex:

Pyruvic acid + NAD+ + CoA → Acetyl CoA + CO2 + NADH

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