Q.How will you convert Ethylacetate into Ethylaceto acetate ?
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Start your 14-day free trial to unlock the full solution →Two molecules of ethyl acetate undergo Claisen condensation, catalysed by sodium ethoxide: the enolate of one molecule attacks the ester carbonyl of the other, kicking out ethoxide to give ethyl acetoacetate.
Ethyl acetate, , has alpha-hydrogens on the group adjacent to the carbonyl, which are acidic enough to be removed by a strong base like sodium ethoxide (), generating an ester enolate: This carbanion/enolate then performs a nucleophilic acyl substitution, attacking the carbonyl carbon of a second molecule of ethyl acetate and displacing ethoxide ion: After acidic workup, the product is ethyl acetoacet …
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