Q.A, B, D are three independently assorting genes with their recessive alleles a, b, d, respectively. A cross was made between individuals of Aa bb DD genotype with aa bb dd. Find out the type of genotypes of the offspring produced.

Showing the 12 most recent of 16 on this concept.

1. TG EAPCET 2026Set ap-2026-05-04-AN1 markMCQ
   Q.Match the following List-1 List-2 A. linkage I. Common in cancer cells B. Recombination II. Parental gene combination C. Point mutation III. Non parental combination D. Chromosomal aberration IV. Sickle cell anemia V. Multiple phenotypes The correct answer is (A) A-II, B-V, C-IV, D-I (B) A-II, B-III, C-IV, D-I (C) A-I, B-IV, C-III, D-V (D) A-II, B-III, C-IV, D-V

   ›Reveal solutionSolution

   This question tests your understanding of key genetic terms and their real-world examples. The correct mapping is A-II, B-III, C-IV, D-I, which corresponds to option (B).

   Let’s build the intuition first. Each term in List-1 describes a specific genetic phenomenon, and List-2 gives either a cause, a consequence, or a classic example. The trick is to match each term with its most direct and well-known association — not just any possible connection, but the one that is textbook-standard for Indian exams.

   1. A. Linkage → II. Parental gene combination

      Linkage means genes located close together on the same chromosome tend to be inherited as a block. They do not assort independently, so the offspring often get the same combination of alleles that the parents had — hence “parental gene combination.” This is the classic definition: linkage preserves parental combinations unless crossing over breaks them.

   2. B. Recombination → III. Non-parental combination

      Recombination is the process that shuffles alleles between homologous chromosomes during meiosis (crossing over). The result is new combinations of genes that were not present together in either parent — these are called “non-parental” or “recombinant” combinations. So B matches III directly.

   3. C. Point mutation → IV. Sickle cell anemia

      A point mutation is a change in a single nucleotide base pair. Sickle cell anemia is the classic example: a single base substitution in the beta-globin gene (GAG → GTG) changes glutamic acid to valine, causing the disease. This is the go-to example in every syllabus.

   4. D. Chromosomal aberration → I. Common in cancer cells …

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2. TG EAPCET 2026Set ap-2026-05-04-AN1 markMCQ
   Q.Study the following and choose the correct statements I. If a single gene influences more than one phenotypic trait, it is called pleiotropy II. Due to absence of antibodies anti A and anti B, the persons with AB blood group are described as universal recipients III. Inheritance of sex linked dominant traits follow cris cross inheritance IV. If sex index ratio is 0.33, then sexual phenotype of Drosophila is intersex (A) I, III (B) II, IV (C) III, IV (D) I, II

   ›Reveal solutionSolution

   Statements I and II are correct; III and IV are wrong, so the correct set is I, II — option (D).

   I – Correct. When a single gene affects several phenotypic traits, the effect is called pleiotropy (e.g. the sickle-cell gene affects RBC shape, anaemia and malaria resistance). This is the standard definition.

   II – Correct. Blood group AB carries both A and B antigens but no anti-A or anti-B antibodies in the plasma, so such persons can receive blood of any ABO type without agglutination — they are universal recipients.

   III – Incorrect. Criss-cross inheritance (father $\to$ daughter $\to$ grandson) is the pattern of X-linked recessive traits. X-linked dominant traits do not show criss-cross inheritance — an affected father passes the trait to all his daughters but to none of his sons. …

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3. TG EAPCET 2025Set ap-2025-04-29-AN1 markMCQ
   Q.The disease sickle cell anemia is caused by substitution of ‘A’ by ‘B’ of ‘C’ globin chain of hemoglobin molecule. Identify A, B and C respectively (A) A – Alanine, B – Glutamic acid, C – Beta (B) A – Glutamic acid, B – Valine, C – Beta (C) A – Valine, B – Glutamic acid, C – Alpha (D) A – Valine, B – Serine, C – Beta

   ›Reveal solutionSolution

   Sickle cell anemia results from a point mutation where glutamic acid is replaced by valine at the sixth position of the beta-globin chain of hemoglobin. The correct option is (B).

   Sickle cell anemia is a classic example of a genetic disorder caused by a single point mutation, leading to a change in a single amino acid in a protein. This seemingly small change has profound effects on the structure and function of hemoglobin, ultimately altering the shape of red blood cells and causing the disease's characteristic symptoms. Understanding this specific molecular change is key to grasping the pathology of sickle cell anemia.

   Here's a breakdown of the molecular basis of sickle cell anemia:

   1. Hemoglobin Structure: Hemoglobin is the oxygen-carrying protein in red blood cells. In adults, it is primarily composed of four polypeptide chains: two alpha ($\alpha$) globin chains and two beta ($\beta$) globin chains. Each chain contains a heme group that binds oxygen.

   2. The Genetic Defect: Sickle cell anemia arises from a mutation in the gene that codes for the beta-globin chain. This is a point mutation, meaning a change in a single nucleotide base pair in the DNA sequence.

   3. Identifying the Globin Chain (C): The specific mutation responsible for sickle cell anemia occurs in the beta ($\beta$) globin chain. This is why the disease is often referred to as a "beta-thalassemia" in some contexts, though sickle cell anemia has its own distinct pathology.

   4. Identifying the Amino Acid Substitution (A and B):

      • At the sixth position of the beta-globin chain, the normal amino acid is glutamic acid (A). Glutamic acid is a hydrophilic (water-loving) amino acid.
      • Due to the point mutation (a change from GAG to GTG in the mRNA codon), valine (B) is substituted in place of glutamic acid at this sixth position. Valine is a hydrophobic (water-fearing) amino acid. …

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4. TG EAPCET 2025Set ap-2025-04-29-AN1 markMCQ
   Q.Study the following and identify the correct combinations

   	Phenomenon	Phenotypic ratio	Genotypic ratio
   I	Co-dominance	$1:2:1$	$1:2:1$
   II	Incomplete dominance	$3:1$	$1:2:1$
   III	Monohybrid test cross	$1:1$	$1:1$
   IV	Dihybrid test cross	$9:3:3:1$	$1:1:1:1$

   (A) I & III (B) II & III (C) II & IV (D) I & II

   ›Reveal solutionSolution

   Only I (co-dominance: $1:2:1$ and $1:2:1$) and III (monohybrid test cross: $1:1$ and $1:1$) are stated correctly. Incomplete dominance gives a $1:2:1$ phenotypic ratio (not $3:1$), and a dihybrid test cross gives $1:1:1:1$ phenotypes (not $9:3:3:1$). Hence the correct combination is I & III — option (A).

   The concept first

   Two different things are being asked in every row:

   • The genotypic ratio comes only from which gametes combine — it is pure Punnett-square bookkeeping and is the same whatever the dominance relationship is.
   • The phenotypic ratio depends on how the alleles interact:
     • Complete dominance — the heterozygote looks like the dominant homozygote, so two genotype classes fuse and $1:2:1$ collapses to $3:1$.
     • Incomplete dominance — the heterozygote is intermediate (e.g. pink Mirabilis), so nothing fuses and the phenotypic ratio equals the genotypic ratio, $1:2:1$.
     • Co-dominance — the heterozygote shows both phenotypes together (e.g. blood group $AB$), so again nothing fuses and the phenotypic ratio equals the genotypic ratio, $1:2:1$.

   So the memorable rule is: in both incomplete dominance and co-dominance, phenotypic ratio $=$ genotypic ratio $= 1:2:1$.

   Step-by-step

   Step 1 — Row I: Co-dominance.

   Cross $I^A I^B \times I^A I^B$ (or any co-dominant heterozygote $\times$ itself). Gametes from each parent: $\tfrac12 I^A,\ \tfrac12 I^B$.

   $\text{Offspring} = \tfrac14 I^A I^A : \tfrac12 I^A I^B : \tfrac14 I^B I^B \;=\; 1:2:1 \text{ (genotypic)}$

   Because the heterozygote expresses both alleles, it is its own distinct phenotype, so the phenotypic ratio is also $1:2:1$. The row says $1:2:1$ and $1:2:1$ — correct.

   Step 2 — Row II: Incomplete dominance.

   $Rr \times Rr$ gives genotypes $RR : Rr : rr = 1:2:1$ — the row's genotypic ratio is right. But the heterozygote $Rr$ is pink, distinct from red $RR$ and white $rr$, so the phenotypes are $1$ red $:2$ pink $:1$ white $= 1:2:1$. The row prints $3:1$, which is the complete-dominance result. Row II is incorrect.

   Step 3 — Row III: Monohybrid test cross.

   A test cross is heterozygote $\times$ recessive homozygote: $Aa \times aa$. Gametes: $\tfrac12 A, \tfrac12 a$ from one side; only $a$ from the other.

   $\text{Offspring} = \tfrac12 Aa : \tfrac12 aa = 1:1$ …

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5. TG EAPCET 2025Set ap-2025-04-29-FN1 markMCQ
   Q.Study the following and identify the correct statements: I. The alleles $I^A$ and $I^B$ regarding blood groups are dominant over $I^O$, and $I^A$ and $I^B$ are co-dominant II. In some fishes, reptiles and birds, females are heterogametic (ZW) and males are homogametic (ZZ). III. Genic balance theory states that Y-chromosome is essential for determination of sex in male Drosophila IV. Person with O blood group are called universal donors because their RBC contain both antigens A and B. (A) I, II (B) III, IV (C) I, III (D) II, IV

   ›Reveal solutionSolution

   The question tests four statements on genetics — blood group inheritance, sex determination in ZW systems, the genic balance theory in Drosophila, and the basis of universal donation. Statements I and II are correct; III and IV are false. The correct option is (A).

   Let’s examine each statement carefully, one by one.

   1. Statement I: The alleles $I^A$ and $I^B$ regarding blood groups are dominant over $I^O$, and $I^A$ and $I^B$ are co-dominant.

      This is textbook ABO blood group genetics. The $I^A$ and $I^B$ alleles each produce a specific antigen (A and B respectively), while $I^O$ produces no functional antigen. Both $I^A$ and $I^B$ are dominant over $I^O$, so a person with genotype $I^A I^O$ has blood group A, and $I^B I^O$ gives group B. When both $I^A$ and $I^B$ are present together, both antigens are expressed equally — that is co-dominance, giving blood group AB.

      Statement I is correct.

   2. Statement II: In some fishes, reptiles and birds, females are heterogametic (ZW) and males are homogametic (ZZ).

      In the ZW sex-determination system, the female has two different sex chromosomes (ZW) and the male has two identical ones (ZZ). This is indeed found in birds, many reptiles, and some fishes. The opposite (XX/XY) system is typical in mammals and Drosophila.

      Statement II is correct.

   3. Statement III: Genic balance theory states that Y-chromosome is essential for determination of sex in male Drosophila.

      This is a classic trap. In Drosophila melanogaster, sex is determined not by the presence of a Y chromosome, but by the ratio of X chromosomes to autosomes (the X:A ratio). The Y chromosome in Drosophila is required only for male fertility, not for male determination. The genic balance theory, proposed by Calvin Bridges, explicitly states that the Y chromosome is not essential for maleness — a fly with XXY is female, and a fly with XO (no Y) is male but sterile.

      Statement III is false. …

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6. TG EAPCET 2025Set ap-2025-04-30-FN1 markMCQ
   Q.Consider the following statements Assertion (A): Skin colour in human beings is a polygenetic trait. Reason (R): Human skin colour is controlled by cumulative effect of genes. The correct answer is (A) Both (A) and (R) are true, (R) is the correct explanation of (A) (B) Both (A) and (R) are true, (R) is not the correct explanation of (A) (C) (A) is true, but (R) is false (D) (A) is false, but (R) is true

   ›Reveal solutionSolution

   Skin colour is polygenic because multiple genes act cumulatively/additively; R explains A.

   Assertion: Skin colour in human beings is a polygenic trait - a phenotype governed by more than one gene, showing a continuous gradation of expression rather than discrete classes. …

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7. TG EAPCET 2024Set ap-2024-05-07-AN1 markMCQ
   Q.Observe the phenotypic ratios given below A. $9:3:3:1$ B. $1:2:1$ C. $1:1$ Arrange the ratios in the order of monohybrid test cross; incomplete dominance; and dihybrid cross (A) B-C-A (B) C-B-A (C) B-A-C (D) A-B-C

   ›Reveal solutionSolution

   A monohybrid test cross gives $1:1$ (ratio C), incomplete dominance gives $1:2:1$ (ratio B) and a dihybrid cross gives $9:3:3:1$ (ratio A). In the order asked, that is C – B – A, i.e. option (B).

   The concept first

   Ratios in genetics are not things to be memorised as trivia — each one is generated by a specific set of gametes, and if you can build the Punnett square you never have to remember anything.

   Two questions decide every ratio:

   1. How many gene pairs are segregating? One → monohybrid arithmetic. Two → multiply the two monohybrid outcomes (Law of Independent Assortment).
   2. Is the heterozygote phenotypically identical to the dominant homozygote, or does it look different? If identical → complete dominance, and genotypes collapse into fewer phenotypes. If different → incomplete dominance, and no collapsing happens.

   Step-by-step

   1. Monohybrid test cross → ratio C ($1:1$). A test cross means crossing an individual of unknown genotype with the homozygous recessive. For a heterozygote:

   $Tt \times tt$

   Gametes: $T$ and $t$ from the first parent; only $t$ from the second.

   Offspring: $\tfrac12\,Tt$ (tall) and $\tfrac12\,tt$ (dwarf).

   $\therefore \text{phenotypic ratio} = 1:1 \;\Rightarrow\; \mathbf{C}$

   This is exactly why a test cross works — a heterozygote betrays itself by producing recessive offspring.

   2. Incomplete dominance → ratio B ($1:2:1$). In Mirabilis jalapa (four o'clock plant), $RR$ = red, $rr$ = white, and $Rr$ is pink — its own distinct phenotype. Selfing the $F_1$:

   $Rr \times Rr \;\rightarrow\; 1\,RR : 2\,Rr : 1\,rr \;=\; 1\ \text{red} : 2\ \text{pink} : 1\ \text{white}$

   Because the heterozygote is visibly different, the $2\,Rr$ class does not merge with the $1\,RR$ class. So the phenotypic ratio equals the genotypic ratio:

   $1:2:1 \;\Rightarrow\; \mathbf{B}$ …

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8. TG EAPCET 2024Set ap-2024-05-07-AN1 markMCQ
   Q.If karyotype of a Drosophila is AA-XXXY, its sexual phenotype is (A) Matafemale (B) Metamale (C) Intersex (D) Female with Y chrosome

   ›Reveal solutionSolution

   In Drosophila, sex is determined by the ratio of X chromosomes to sets of autosomes (the sex index). For a karyotype of AA-XXXY, the sex index is $1.5$, which results in a Metafemale phenotype.

   The sexual phenotype of Drosophila is determined by a mechanism known as the genic balance theory, proposed by C.B. Bridges. Unlike humans where the presence of a Y chromosome primarily determines maleness, in Drosophila, the balance between the number of X chromosomes and the number of sets of autosomes dictates the sex. The Y chromosome in Drosophila is primarily involved in male fertility, not sex determination itself.

   This balance is quantified by the "sex index," which is calculated as the ratio of the number of X chromosomes (X) to the number of sets of autosomes (A).

   Sex Index $(I) = \frac{\text{Number of X chromosomes}}{\text{Number of sets of autosomes}}$

   Different values of this index correspond to different sexual phenotypes:

   • $I = 1.0$: Normal Female
   • $I > 1.0$: Metafemale (also called Superfemale)
   • $I = 0.5$: Normal Male
   • $I < 0.5$: Metamale (also called Supermale)
   • $0.5 < I < 1.0$: Intersex

   Let's apply this concept to the given karyotype.

   1. Identify the number of X chromosomes: The given karyotype is AA-XXXY. Here, 'XXXY' indicates there are three X chromosomes. So, $X = 3$.

   2. Identify the number of sets of autosomes: The 'AA' in the karyotype represents two sets of autosomes. So, $A = 2$. …

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9. TG EAPCET 2024Set ap-2024-05-07-FN1 markMCQ
   Q.The table given below is related to checker board of dihybrid F$_2$ progeny of Mendel’s experiment. Identify correct combinations Genotype | Phenotype | Number of genotypes I YYRr Yellow Round 2 II YyRr Yellow Round 1 III yyRR Green Round 4 IV yyRr Green Round 2 Options : (A) I and II (B) II and IV (C) III and IV (D) I and IV

   ›Reveal solutionSolution

   In the 16-square dihybrid Punnett square, YYRr appears 2 times and yyRr appears 2 times (both correct), while YyRr appears 4 (not 1) and yyRR appears 1 (not 4). The correct combinations are I and IV — option (D).

   The concept first

   The dihybrid $F_2$ is nothing more than two independent monohybrid crosses multiplied together — that is Mendel's Law of Independent Assortment in action. $YyRr$ makes four gamete types, $YR,\ Yr,\ yR,\ yr$, in equal $1:1:1:1$ proportion, so the checker board has $4 \times 4 = 16$ boxes.

   Because the loci are independent, the number of boxes for any genotype is just the product of its two single-locus frequencies out of 4:

   $\text{homozygote at a locus} \to 1/4,\qquad \text{heterozygote at a locus} \to 2/4$

   So:

   • homozygous at both loci → $1 \times 1 = \mathbf{1}$ box,
   • heterozygous at one locus → $2 \times 1 = \mathbf{2}$ boxes,
   • heterozygous at both loci → $2 \times 2 = \mathbf{4}$ boxes. That single rule answers the whole question without drawing anything.

   Step-by-step

   1. Write the full $F_2$ genotypic ratio (the 9 genotypes in 16 boxes):

   $1\,YYRR : 2\,YYRr : 2\,YyRR : 4\,YyRr : 1\,YYrr : 2\,Yyrr : 1\,yyRR : 2\,yyRr : 1\,yyrr$

   (These 16 collapse into the familiar phenotypic $9:3:3:1$.) …

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10. TG EAPCET 2023Set ap-2023-05-10-FN1 markMCQ
    Q.Study the following tables and match the correct combination for the dihybrid $F_2$ progeny Genotype Phenotype Genotypes Number I YYRr Yellow round 2 II $Y_yRr$ Yellow round 1 III yyRR Green round 4 IV yyRr Green round 2 (A) III and IV (B) II and IV (C) I and II (D) I and IV

    ›Reveal solutionSolution

    In a dihybrid cross (YyRr × YyRr), the $F_2$ progeny follow a 9:3:3:1 phenotypic ratio. The table lists genotypes and their counts; we must match each row to the correct number of individuals. The correct combination is I and IV.

    The question tests your understanding of Mendelian dihybrid inheritance — specifically, the genotypic and phenotypic ratios that arise from a cross between two double heterozygotes ($YyRr \times YyRr$). The key is to recall that each trait (seed colour and seed shape) segregates independently, giving a 9:3:3:1 phenotypic ratio in the $F_2$ generation. But here, the table gives specific genotypes and asks you to verify the number of individuals with that genotype.

    Let’s break it down step by step.

    1. Set up the cross.

       Both parents are $YyRr$ (yellow, round). The gametes produced are $YR$, $Yr$, $yR$, $yr$ in equal proportions (1:1:1:1). The Punnett square for a dihybrid cross has 16 equally likely combinations.

    2. Determine the expected genotypic frequencies.

       For any one gene pair, the monohybrid ratio is $1:2:1$ (e.g., $YY:Yy:yy$). Since the two genes assort independently, the combined genotypic ratio is the product of the two monohybrid ratios.

       • For colour: $YY$ (1), $Yy$ (2), $yy$ (1).
       • For shape: $RR$ (1), $Rr$ (2), $rr$ (1). Multiply these to get the 16-cell Punnett square frequencies. For example, $YYRR$ appears $1 \times 1 = 1$ time, $YyRr$ appears $2 \times 2 = 4$ times, etc.

    3. Match each row in the table to the expected count.

       • Row I: $YYRr$ — genotype $YY$ (1) × $Rr$ (2) = 2 individuals. The table says 2. Correct.
       • Row II: $YyRr$ — $Yy$ (2) × $Rr$ (2) = 4 individuals. The table says 1. Incorrect. …

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11. TG EAPCET 2023Set ap-2023-05-10-AN1 markMCQ
    Q.Study the following and pick up the correct combinations S.No. Hormone Gland Effect of Hyper / Hyposecretion I Vasopressin Pituitary gland Diabetes insipidus II Calcitonin Parathyroid gland Cretinism III Cortisol Adrenal gland Addison's disease IV Insulin Pancreas Diabetes insipidus (A) I, II (B) III, IV (C) I, III (D) II, IV

    ›Reveal solutionSolution

    The question tests your knowledge of hormones, their source glands, and the diseases caused by their abnormal secretion. Only combinations I (Vasopressin → Pituitary → Diabetes insipidus) and III (Cortisol → Adrenal → Addison's disease) are correct, so the answer is option (C).

    The key here is to match each hormone with its correct gland and then with the specific disorder caused by either hypo- or hypersecretion. Many students mix up glands (like parathyroid vs. thyroid) or confuse diseases (like diabetes insipidus vs. mellitus). Let’s check each row carefully.

    1. Row I: Vasopressin – Pituitary gland – Diabetes insipidus

       Vasopressin (also called antidiuretic hormone, ADH) is secreted by the posterior pituitary. Its main job is to increase water reabsorption in the kidneys. When secretion is too low (hyposecretion), the kidneys cannot concentrate urine, leading to diabetes insipidus — excessive dilute urine and thirst. This match is correct.

    2. Row II: Calcitonin – Parathyroid gland – Cretinism

       Calcitonin is actually secreted by the thyroid gland (parafollicular cells), not the parathyroid. The parathyroid glands secrete parathyroid hormone (PTH). And cretinism is caused by hyposecretion of thyroid hormone (thyroxine) during childhood, not by calcitonin issues. So both the gland and the disease are wrong. This row is incorrect.

    3. Row III: Cortisol – Adrenal gland – Addison's disease …

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12. TG EAPCET 2023Set ap-2023-05-11-FN1 markMCQ
    Q.Inhalation of iron particles causes (A) Pneumoconiosis (B) Pneumonia (C) Emphysema (D) Black lung disease.

    ›Reveal solutionSolution

    Chronic inhalation of iron dust particles leads to deposition in the lungs, causing pneumoconiosis — specifically a form called siderosis. The answer is (A).

    Pneumoconiosis is the umbrella term for any lung disease caused by the inhalation and accumulation of mineral or metallic dust particles. The name itself tells the story: pneumo- (lung) + coni- (dust) + -osis (condition). Different dusts produce different variants of the disease, each with its own name and characteristics.

    When iron particles are inhaled occupationally — in welding shops, iron ore mines, steel mills — they settle deep in the alveoli and interstitial tissue. The body cannot effectively clear these inert particles, so they accumulate over years. Macrophages engulf the iron dust, and the lung tissue responds with fibrosis in severe cases. This iron-induced pneumoconiosis is specifically called siderosis (from the Greek sideros, iron).

    Let's see why the other options don't fit:

    1. Pneumonia (B) is an acute infection of the lung parenchyma caused by bacteria, viruses, or fungi. It presents with fever, productive cough, and consolidation on imaging. Iron dust is not infectious and does not cause the inflammatory exudate characteristic of pneumonia. …

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