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Q.Read the following passage and answer the question that follow : The data below shows the concentration of nicotine smoked by a smoker taking 10 puffs/minute. [Line graph 'Smoking Cigarette': X-axis Time (minutes) 1–15; Y-axis Concentration of Nicotine in blood (mg/cm³) 0–50. Concentration rises steadily from ~2 (at 1 min) to a peak of ~45 (at 10 min), then falls sharply to ~20 (at 11 min) and declines to ~10 by 15 min.]

(a)
(i) With reference to the above graph, explain the concentration of nicotine in the blood at 10 minutes.
(OR)
(a)
(ii) How will this affect the concentration of carbon monoxide and haem-bound oxygen at 10 minutes ?
(b) How does cigarette smoking result in high blood pressure and increase in heart rate ?
(c) To which class of compounds does nicotine belong ? Name one other drug from the same class.
CBSECBSE Class XII Board 2026Subjective· 4mImportance★★★★★
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Part (a): nicotine peaks (~45 units) at 10 min because continuous puffing gives cumulative rapid absorption.

Part (b): CO rises and haem-bound O₂ falls (carboxyhaemoglobin); nicotine raises BP and heart rate via adrenaline/noradrenaline (vasoconstriction + cardiac stimulation); nicotine is an alkaloid (e.g. cocaine).

Part (a)

(a)(i) The nicotine concentration at 10 minutes

The line graph tracks blood nicotine while a person smokes at 10 puffs per minute. The curve climbs steadily from ~2 units at 1 minute to a maximum of about 45 units at 10 minutes, then drops steeply once puffing slows.

The peak at 10 minutes occurs because:

  • each puff delivers nicotine that is very rapidly absorbed through the large alveolar surface of the lungs into the bloodstream, and
  • with continuous puffing this input accumulates faster than the liver can metabolise/excrete it, so the blood level is highest at the end of the 10-minute smoking bout. …

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