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Q.Give one use of CHI3CHI_3.

CBSECBSE Class XII Board 2020Subjective· 1mImportance★★★★★
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The compound CHI3CHI_{3} (iodoform) is used as an antiseptic — it was historically applied to disinfect wounds and surgical instruments, though its use has declined due to toxicity concerns.

Why iodoform works as an antiseptic

Iodoform is a yellow, crystalline solid with a characteristic pungent odour. Its antiseptic property comes from the slow release of free iodine when it comes into contact with body fluids or microbial enzymes. Free iodine is a powerful germicide — it oxidises microbial proteins, disrupts cell membranes, and kills bacteria, fungi, and even some viruses.

The key insight: iodoform itself is relatively stable, but in a moist, warm environment (like a wound), it decomposes gradually:

CHI3→moisture/enzymesiodine species+by-productsCHI_{3} \xrightarrow{\text{moisture/enzymes}} \text{iodine species} + \text{by-products}

This sustained release means a single application provides prolonged antiseptic action, unlike tincture of iodine which acts quickly but evaporates or gets absorbed fast.

Step-by-step reasoning

  1. Identify the compound — CHI3CHI_{3} is iodoform, a trihalomethane where three iodine atoms replace three hydrogens of methane. It is prepared industrially by the haloform reaction (e.g., from ethanol or acetone with iodine and base).

  2. Recall the historical medical context — Before modern antibiotics, antiseptics were crucial for preventing wound infections. Iodoform was widely used in the late 19th and early 20th centuries as a surgical dressing, often as a powder or in gauze.

  3. Understand the mechanism — Iodoform does not kill microbes directly. Instead, it acts as a prodrug for iodine. In the presence of moisture and tissue enzymes, it undergoes slow hydrolysis/oxidation to release elemental iodine (I2I_{2}) and other iodine-containing species. Iodine then penetrates microbial cell walls and oxidises essential thiol groups in enzymes, killing the pathogen. …

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