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Biology · Ch 12 — Biotechnology

Healthcare Biotechnology

12.4.1

Healthcare Biotechnology

Healthcare biotechnology refers to medicinal or diagnostic products, or vaccines, developed using biotechnology, and it has had a tremendous impact on meeting patient needs. It offers patients unique, targeted and personalised therapeutic and diagnostic solutions -- for organ transplantation, stem-cell technology, genetic counselling, forensic medicine, gene probes, genetic fingerprinting and karyotyping are all outcomes of this branch of biotechnology. Table 12.7 lists a range of human recombinant proteins now produced by rDNA technology specifically to treat disease -- for example, erythropoietin for anaemia, insulin for diabetes, Factor VIII and Factor IX for haemophilia A and B, tissue plasminogen activator for blood clots, interferons for cancer, and the hepatitis B va …

Table 12.7Human proteins produced by rDNA technology to treat human diseases
Disease/ConditionRecombinant Protein/Product
AnaemiaErythropoietin
AsthmaInterleukin-1 receptor
AtherosclerosisPlatelet-derived growth factor
Parturition (childbirth)Relaxin
Blood clotsTissue Plasminogen Activator (TPA), Urokinase
CancerInterferons, tumour necrosis factor, interleukins, macrophage-activating factor
DiabetesInsulin
EmphysemaAlpha-1 antitrypsin