Q.Can there be DNA replication without cell division?

Yes, DNA can be replicated without the cell going on to divide.

• DNA synthesis (in the S phase) and cell division (the M phase) are separate events, and the two do not always have to follow each other.
• Nuclear division and cytoplasmic division can also be uncoupled: in some organisms the nucleus divides repeatedly but the cytoplasm does not, leaving many nuclei in one common cytoplasm — a multinucleate condition called a syncytium. …

The events of duplicating the genetic material and dividing the cell are coordinated in a normal cell cycle, but they are distinct steps, and they need not always go together. This becomes clear when we look at what happens to karyokinesis and cytokinesis.

Replication and division are separate steps

• DNA synthesis is a distinct stage (the S phase); the physical division of the cell is a separate stage (the M phase).
• Nuclear division (karyokinesis) and the division of the cytoplasm (cytokinesis) do not always accompany one another either.

When division does not follow

• In some organisms, nuclear division takes place but is not followed by the division of the cytoplasm.
• When this happens repeatedly, the cell ends up with many nuclei sharing a common cytoplasm — a multinucleate condition known as a syncytium. …

Step 1 — Separate DNA replication (S phase) from cell division (M phase) as two distinct, in-principle-separable events.

Step 2 — Go one level further: karyokinesis and cytokinesis can also be uncoupled — nuclear division without cytoplasmic division. …