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Exercises · 10.16

Q.Analyse the events during every stage of cell cycle and notice how the following two parameters change

(i) number of chromosomes (N) per cell
(ii) amount of DNA content (C) per cell
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Through the cell cycle the chromosome number (N) stays constant at 2n during interphase, but the DNA amount (C) doubles from 2C to 4C when the DNA is replicated in the S phase and returns to 2C in each daughter cell after mitosis.

The key to this question is to keep two ideas separate: the number of chromosomes and the amount of DNA. These do not change at the same points in the cycle, and confusing them is a common mistake.

G1 phase

  • The cell has just come out of mitosis. It is metabolically active and growing, but it has not yet copied its DNA.
  • Chromosome number is 2n (diploid); DNA content is at the starting level, which we write as 2C.

S phase

  • This is the period of DNA synthesis, when the DNA is replicated.
  • The amount of DNA per cell doubles — from 2C up to 4C.
  • Crucially, the chromosome number does not change: a cell that was 2n before S phase is still 2n afterwards. Each chromosome now consists of two chromatids, so there is more DNA, but the count of chromosomes is the same.

G2 phase

  • The cell continues to grow and makes proteins in readiness for mitosis.
  • Chromosome number is still 2n; DNA content remains at 4C.

M phase and the daughter cells

  • During mitosis the sister chromatids are separated equally into two daughter nuclei. …

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