Q.What is sex-linked inheritance? Discuss the inheritance of haemophilia.
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Morgan's Fruit Fly Experiments: A First Look
Imagine you're trying to understand how traits pass from parents to children. You could study humans, but that takes decades — one generation every 25 years. What if you could watch a hundred generations in a single year? That's exactly what Thomas Hunt Morgan realised when he picked the fruit fly, Drosophila melanogaster, for his experiments around 1910.
Why Fruit Flies?
Morgan needed an organism that was cheap, fast-breeding, and easy to handle. Fruit flies fit perfectly. They breed every 10–14 days, produce hundreds of offspring, and have just four pairs of chromosomes — simple enough to track. More importantly, they show clear, visible traits: eye colour (red or white), wing shape (normal or vestigial), body colour (grey or black). These traits became Morgan's window into how genes work.
The Breakthrough: The White-Eyed Male
Morgan started by breeding normal red-eyed flies. Then, by chance, he found a single male with white eyes — a mutant. He crossed this white-eyed male with a red-eyed female. All the offspring (the F1 generation) had red eyes. That told him red eye colour was dominant over white.
Then came the crucial step. He bred those F1 red-eyed flies with each other. In the F2 generation, he got a surprise: all the females had red eyes, but half the males had white eyes. The white-eye trait appeared only in males.
This was the first clear experimental evidence that a specific gene is located on a specific chromosome — in this case, the X chromosome. The white-eye gene is on the X chromosome, and males have only one X, so they express whatever is on it. Females have two X's, so a recessive white-eye gene can be hidden by a dominant red-eye gene on the other X.
What Morgan Proved
Before Morgan, scientists knew chromosomes existed, but no one had proven that a particular gene lived on a particular chromosome. Morgan's fruit fly experiments did exactly that. He showed that:
- Genes are physical units located on chromosomes
- The inheritance of a trait (white eyes) follows the inheritance pattern of a specific chromosome (the X)
- Sex-linked traits — those carried on the X chromosome — behave differently in males and females
This was the birth of the chromosomal theory of inheritance. It connected Mendel's abstract "factors" (genes) to real, visible structures inside cells.
Why It Matters for a Commerce/Humanities Student
You might think this is pure biology, but the principle here is about evidence linking a cause to an effect. Morgan didn't just guess that genes were on chromosomes — he designed an experiment where the pattern of inheritance forced that conclusion. This is the same logic used in economics (linking policy changes to market outcomes) or law (linking evidence to a verdict). The method matters as much as the result. …
Sex-linked inheritance is the inheritance of genes located on the sex chromosomes; haemophilia is an X-linked recessive disorder of blood clotting transmitted through carrier females to their sons. …
Sex-linked inheritance = inheritance of genes on the sex chromosomes; haemophilia is an X-linked recessive clotting disorder passed from carrier mothers to sons (criss-cross).
Sex-linked inheritance is the inheritance of characters whose genes are located on the sex chromosomes (X or Y) rather than the autosomes. Genes on the X chromosome show X-linked inheritance and those on the Y show Y-linked (holandric) inheritance. Because males are XY (hemizygous), a single recessive allele on their one X chromosome is expressed, so X-linked recessive traits appear more often in males and are transmitted by criss-cross inheritance (father → carrier daughter → grandson).
Inheritance of haemophilia (bleeder's disease):
Haemophilia is an X-linked recessive disorder in which the blood fails to clot (or clots very slowly) because a clotting factor (Factor VIII in haemophilia-A, Factor IX in haemophilia-B) is deficient; even a minor injury may cause continuous bleeding.
Let X^H = normal allele (dominant), X^h = haemophilia allele (recessive).
- Cross: Carrier female (X^H X^h) × Normal male (X^H Y):
- Daughters: ½ X^H X^H (normal), ½ X^H X^h (carrier).
- Sons: ½ X^H Y (normal), ½ X^h Y (haemophilic). …
Showing the 12 most recent of 14 on this concept.
- CBSE 2025Set 57/5/11 markMCQQ.Assertion (A) : Gene pairs present on the same chromosome may be tightly linked or loosely linked. Reason (R) : Frequency of recombination between gene pairs on different chromosomes as a measure of the distance between genes can be used for 'mapping' their position on the chromosomes.
›Reveal solutionSolution
Assertion (A) is true because genes on the same chromosome can be tightly or loosely linked depending on their distance. Reason (R) is false because recombination frequency is used to map genes on the same chromosome, not different chromosomes.
Concept and Intuition
This question tests your understanding of gene linkage and gene mapping. Genes located on the same chromosome are called linked genes. They tend to be inherited together because they are physically connected. However, this inheritance is not absolute due to a process called crossing over (or recombination) during meiosis.
- Tight Linkage: If two genes are very close to each other on the same chromosome, the probability of a crossover event occurring between them is low. This means they are "tightly linked" and are very likely to be inherited together.
- Loose Linkage: If two genes are farther apart on the same chromosome, the probability of a crossover event occurring between them is higher. This means they are "loosely linked" and there's a greater chance they will be separated during meiosis, leading to recombination.
The frequency of recombination (the percentage of recombinant offspring) is directly proportional to the physical distance between linked genes on a chromosome. This relationship is fundamental to gene mapping, where geneticists use recombination frequencies to determine the relative positions of genes and construct genetic maps. It's crucial to remember that this principle applies to genes on the same chromosome. Genes on different chromosomes assort independently, and their recombination frequency is typically 50%, which doesn't reflect a physical distance on a chromosome.
Step-by-step Evaluation
- Analyze Assertion (A): Gene pairs present on the same chromosome may be tightly linked or loosely linked. …
- CBSE 2025Set F1 markMCQQ.What is the number of linkage groups in human being?(a) 46(b) 22(c) 92(d) 23
›Reveal solutionSolution
Linkage groups = haploid chromosome number; in humans that is 23.
All the genes located on one chromosome are inherited together and form a linkage group. Therefore the number of linkage groups in a species equals its haploid (n) number of chromosomes — the number of different chromosome types.
…
- CBSE 2024Set ANNUAL1 markMCQQ.Lack of independent assortment of two genes 'A' and 'B' in fruit fly Drosophila is due to(a) Repulsion(b) Recombination(c) Linkage(d) Crossing over
›Reveal solutionSolution
Genes located close together on the same chromosome show linkage, deviating from independent assortment.
Morgan's classic experiments with the fruit fly Drosophila melanogaster demonstrated that when two genes are located on the same chromosome, they tend to be inherited together (rather than assorting independently, as predicted by Mendel's Law of Independent Assortment for genes on different chromosomes) — a phenomenon he termed linkage. Genes on the same chromosome that show a strong tendency to stay together during inheritance are said to be "tightly linked," while genes farther apart on the same chromosome show more crossing over and behave more like independently assorting genes ("loosely link …
- CBSE 2023Set ANNUAL1 markQ.What is crossing over?
›Reveal solutionSolution
Crossing over reshuffles alleles between homologous chromosomes during meiosis, and is a key source of genetic recombination/variation.
Crossing over occurs during the pachytene stage of prophase I of meiosis, after homologous chromosomes have paired up (synapsis) to form a bivalent/tetrad. At specific points called chiasmata, non-sister chromatids of the two homologous chromosomes break and rejoin, exchanging corresponding segments of DNA. This process shuffles the combination of alleles present on each chromosome, generating new (recombinant) allele combinations in the gametes that were not present in either parent chro …
- CBSE 2023Set ANNUAL1 markMCQQ.Crossing over is a characteristic of which stage?(a) leptotene(b) zygotene(c) pachytene(d) diakinesis
›Reveal solutionSolution
Crossing over occurs at the pachytene stage.
During prophase-I of meiosis, homologous chromosomes pair (synapsis) at zygotene, and at pachytene the paired homologues (bivalents) undergo crossing over — reciprocal exchange of segments between non-sister chromatids, mediated by recombination nodules. The points of exchange …
- CBSE 2021Set D1 markMCQQ.An exception of Mendel's law is(a) Dominance(b) Purity of gamete(c) Linkage(d) Independent assortment
›Reveal solutionSolution
Linkage violates Mendel's law of independent assortment, so the answer is (C).
Mendel's law of independent assortment states that alleles of different genes assort independently during gamete formation. This holds true only when the genes are located on different chromosomes.
…
- CBSE 2021Set D1 markMCQQ.In which stage does crossing-over take place ?(a) Leptotene(b) Cytokinesis(c) Pachytene(d) Diakinesis
›Reveal solutionSolution
Crossing-over takes place in the pachytene stage of meiosis I.
During prophase I of meiosis the homologous chromosomes pair (synapsis) at zygotene. In the next stage, pachytene, the paired homologues (bivalents) develop recombination nodules and the enzyme recombinase brings about crossing-over — the reciprocal exchange of genetic material between non-sister chromatids. The points of exchange appear later as chiasmata at diplotene. Leptotene …
- CBSE 2019Set 57/3/11 markQ.What is 'Saltation' according to de Vries ?
›Reveal solutionSolution
De Vries proposed that evolution occurs through saltation — large, discontinuous jumps producing new species in a single generation, rather than gradual accumulation of small changes.
Hugo de Vries, working at the turn of the 20th century, challenged Darwin's gradualism with observations that seemed revolutionary at the time. To understand saltation, we need to see what puzzled him about the prevailing view.
Darwin's theory rested on slow, continuous variation — tiny changes accumulating over vast stretches of time until populations diverged into new species. But de Vries, experimenting with the evening primrose Oenothera lamarckiana, observed something startling: occasional offspring that looked dramatically different from their parents, breeding true in subsequent generations. These weren't minor tweaks; they were large, discrete morphological leaps.
De Vries's concept of saltation
Saltation (from Latin saltare, "to leap") refers to evolution by sudden, large mutations that produce new species instantaneously — in a single generation. De Vries called these dramatic variants mutants and argued they represented the true mechanism of speciation.
His key claims were:
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Discontinuous variation is the raw material of evolution. Small, continuous variations (what Darwin emphasized) merely produce varieties within a species but cannot cross the threshold into a new species.
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Mutations are large-effect changes. A single mutational event creates an organism so different it constitutes a new species immediately, without intermediate forms.
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Species arise in single steps. There is no gradual transition — one generation belongs to the parent species, the next to a new one.
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Natural selection acts only as a sieve. It eliminates unfit mutants but does not create novelty; the mutation itself does all the creative work.
Watch outDe Vries's "mutations" in Oenothera turned out to be mostly chromosomal aberrations (aneuploids, translocations) rather than true gene mutations. The evening primrose has a complex, unusual genetic system that made it a misleading model organism.
Why saltation appealed (and why it faded) …
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- CBSE 2019Set HE1 markQ.Fill in the blank: Drosophila melanogaster work was done by ______.
›Reveal solutionSolution
Detailed genetic work on Drosophila melanogaster was carried out by Thomas Hunt Morgan, establishing the chromosomal theory of inheritance.
Thomas Hunt Morgan chose Drosophila melanogaster (the common fruit fly) as his experimental organism because it could be grown on simple synthetic medium in the laboratory, completed its life cycle in about two weeks, had a short reproductive cycle producing hundreds of offspring in one mating, showed clear sex differences between males and females, and had many easily visible hereditary variations (e.g., body colour, eye colour, wing shape). Using Drosophila, Morgan and his group demonstrated …
- CBSE 2019Set ANNUAL1 markMCQQ.Morgan's experiments were on(a) housefly(b) fruit fly(c) sand fly(d) mosquito
›Reveal solutionSolution
Morgan's foundational genetics experiments used the fruit fly, Drosophila melanogaster.
Thomas Hunt Morgan and his colleagues used the fruit fly, Drosophila melanogaster, as their experimental organism because it is easy to grow in the laboratory on simple synthetic medium, completes its life cycle in about two weeks, produces a large number of offspring, shows clear-cut hereditary variations (e.g., red vs white eye colour), and has just four pairs of chromosomes that are easy to distinguish morphologically. Through breeding experiments (notably the white-eye/red-eye X-linked trait), Morgan provided t …
- CBSE 2019Set ANNUAL1 markQ.Name the scientist who coined the term 'linkage'.
›Reveal solutionSolution
T. H. Morgan, working on Drosophila, coined the term 'linkage' to describe genes located on the same chromosome that tend to be inherited together.
While Bateson and Punnett first observed (in sweet pea, 1906) that some gene combinations did not assort independently as Mendel's laws predicted, it was Thomas Hunt Morgan, through his extensive breeding experiments on the fruit fly Drosophila melanogaster, who explained this phenomenon and coined the term 'linkage' for g …
- CBSE 2019Set ANNUAL1 markQ.Genetic exchange takes place in ____ phase.
›Reveal solutionSolution
Crossing over — the exchange of chromosome segments between non-sister chromatids of homologous chromosomes — occurs at the pachytene sub-stage of meiotic prophase I, and is the physical basis of genetic recombination.
Meiotic prophase I is divided into five sub-stages: leptotene, zygotene, pachytene, diplotene, and diakinesis.
- In zygotene, homologous chromosomes pair up (synapsis) to form bivalents/tetrads. …
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