Evaluation · Q8
Q.Colchicine prevents the mitosis of the cells at which of the following stage
(a) Anaphase
(b) Metaphase
(c) Prophase
(d) interphase
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Start your 14-day free trial to unlock the full solution →Step 1. Colchicine is a mitotic poison that binds tubulin and prevents it from properly polymerising into functional spindle microtubules.
Step 2. Because the spindle cannot form correctly, chromosomes cannot become properly attached via their kinetochores.
Step 3. The spindle assembly checkpoint detects this failure and will not allow the cell to proceed from metaphase into anaphase, so the cell becomes arrested at metaphase, with condensed chromosomes unable to align or move on. …
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