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Question 24 of 30

Q.Tabulate the differences between DNA and RNA.

Tamil Nadu DgeTamil Nadu HSC First Year (DGE) Board 2023Subjective· 3mImportance★★★★★
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DNA and RNA differ chiefly in their sugar (deoxyribose vs ribose), strandedness (double vs single), one base (thymine vs uracil), stability, and function (genetic storage vs protein synthesis/expression).

Both DNA and RNA are nucleic acids, polymers of nucleotide units (each nucleotide made of a pentose sugar, a phosphate group, and a nitrogenous base). Their differences can be tabulated as follows:

Sugar component: DNA contains deoxyribose sugar (which lacks an oxygen atom at the 2' carbon compared to ribose). RNA contains ribose sugar (which has an -OH group at the 2' carbon).

Strandedness: DNA is typically double-stranded, forming the well-known double helix, with two complementary antiparallel strands held together by hydrogen bonds between base pairs. RNA is typically single-stranded (though it can fold back on itself to form local double-stranded/hairpin regions).

Nitrogenous bases: Both share adenine (A), guanine (G), and cytosine (C). But DNA uses thymine (T) as its fourth base, while RNA uses uracil (U) instead of thymine.

Stability: DNA, being double-stranded and lacking the reactive 2'-OH group, is chemically more stable, making it well suited for long-term storage of genetic information. RNA, being single-stranded and possessing the reactive 2'-OH group, is comparatively less stable and more prone to degradation.

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