Q.Write a note on Addison's disease and Cushing's syndrome.

Adrenal Gland Hormones – From Intuition to Precision

Think of your body as a finely tuned machine that needs to handle both daily stress and sudden emergencies. The adrenal glands sit like tiny caps on top of your kidneys, and they are your body's command centre for managing these situations. They produce hormones that help you either deal with long-term stress (like a tough exam week) or react instantly to danger (like a car swerving toward you).

The gland has two distinct parts: the outer cortex and the inner medulla. Each secretes a different class of hormones with different jobs.

The Cortex – Corticoids (Steroid Hormones)

The adrenal cortex produces corticoids, which are steroid hormones derived from cholesterol. They fall into two main groups.

Glucocorticoids (mainly cortisol) regulate your body's use of glucose, proteins, and fats. When you are under prolonged stress, cortisol raises blood sugar by breaking down proteins and fats, giving you sustained energy. It also suppresses inflammation and the immune response — which is why synthetic cortisol (like hydrocortisone) is used in allergy and arthritis treatments.

Mineralocorticoids (mainly aldosterone) control the balance of salt and water in your body. Aldosterone tells your kidneys to hold onto sodium and excrete potassium. Where sodium goes, water follows — so aldosterone indirectly regulates blood volume and blood pressure.

The Medulla – Adrenaline and Noradrenaline (Catecholamines)

The adrenal medulla produces adrenaline (epinephrine) and noradrenaline (norepinephrine). These are not steroids — they are derived from the amino acid tyrosine and act much faster than corticoids.

This is your fight-or-flight system. When you face sudden danger, the medulla dumps adrenaline into your bloodstream. Within seconds, your heart beats faster, your airways widen, blood is diverted to muscles, and your liver releases glucose for quick energy. Noradrenaline works similarly but also constricts blood vessels to raise blood pressure.

Putting It All Together

| Gland Part | Hormones | Type | Main Function | Speed |

|------------|----------|------|---------------|-------| …