Worked Examples · Example 17
Q.Nembutal, a sodium salt (sodium pentobarbital) acts as a sedative and has many applications. Suppose Nembutal is used to anesthetize a dog. The dog is anesthetized when its blood stream concentration contains at least 45mg of sodium pentobarbital per kg of the dog's body weight. If the rate of change of sodium pentobarbital say, in the body, is proportional to the amount of drug present in the body. Show that sodium pentobarbital is eliminated exponentially from the dog's blood stream given that its half-life is 5 hours. What single dose should be administered in order to anesthetize a 50 Kg dog for 1 hour?
Puducherry CbseNCERTSubjective· 5mImportance★★★★★
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Start your 14-day free trial to unlock the full solution →Because the elimination rate is proportional to the amount present, ; the -hour half-life gives /hr, and requiring the concentration to still be mg/kg after hour gives an initial dose of about mg for a kg dog.
, with half-life .
- = amount (concentration) of drug at time
- = initial dose/concentration, = elimination constant per hour.
Show exponential elimination
- “Rate of change proportional to amount present” and the drug is being removed, so
- Separate variables and integrate:
- Exponentiate: where is the amount at . Hence elimination is exponential.
Find from the half-life
- Half-life hr means at :
Required single dose
- Work in concentration (mg per kg body weight): . The dog stays anaesthetized while ; the concentration is lowest at the end of the hour, so we need : …
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