Q.Predict the effects of removal of pancreas from the human body.

Step 1. The pancreas is the source of two glucose-regulating hormones, insulin (lowers blood glucose) and glucagon (raises blood glucose), secreted from its Islets of Langerhans.

Step 2. Removing the pancreas eliminates insulin secretion entirely, so glucose can no longer be taken up efficiently into muscle and fat cells, and its production from glycogen/amino acids/fat is no longer restrained — blood glucose rises sharply and persistently.

Step 3. This produces the clinical picture of severe diabetes mellitus: polyuria (excess urination), polyphagia (excess hunger), polydipsia (excess thirst), ketosis (ketone body build-up from fat breakdown), and gluconeogenesis. …

Reason from the pancreas's two named endocrine hormones (insulin, glucagon) to predict the glucose-regulation consequence of …

• Focusing only on the loss of insulin and forgetting glucagon is also lost, or forgetting the pancreas's exocrine dig …