Q.Write a note on denaturation of proteins

Step 1. Every protein has a unique 3-D structure held together by disulphide bonds, hydrogen bonds, and hydrophobic/electrostatic interactions (§14.2.7).

Step 2. These stabilising interactions can be disrupted by exposure to high temperature, certain chemicals such as urea, or a change in pH or ionic strength, causing partial or complete loss of the protein's higher-order (secondary/tertiary/quaternary) structure while its primary sequence remains unbroken -- this loss of shape is what is called denaturation. …

Recall the definition, causes, consequence (loss of function) and reversibility of …

• Implying that denaturation changes the amino-acid sequence itself -- denaturation specifically leaves the PRIMARY structure (sequence) intact; only the higher-order folding is disrupte …