Q.Allergy involves (A) IgE (B) IgG (C) IgA (D) IgM

Showing the 12 most recent of 13 on this concept.

1. CBSE 2026Set 57/2/11 markMCQ
   Q.What is the role of histamine released by mast cells ? (A) Lowers blood pressure (B) Causes allergic symptoms (C) Stimulates antibody formation (D) Destroys pathogens

   ›Reveal solutionSolution

   Histamine released by mast cells is a crucial chemical mediator responsible for triggering and manifesting the various symptoms associated with allergic reactions.

   Our immune system is a complex network designed to protect us from harmful invaders. However, sometimes it can overreact to harmless substances, leading to what we call allergies. In these allergic responses, certain cells play a pivotal role, and among them, mast cells are key players, primarily through their release of a chemical called histamine.

   Mast cells are a type of white blood cell, specifically granulocytes, that are found in connective tissues throughout the body, particularly in areas exposed to the external environment like the skin, lungs, and digestive tract. They are essentially sentinel cells, poised to respond to perceived threats. When an individual who is sensitive to a particular substance (an allergen) encounters it, their immune system mounts an exaggerated response. This involves the production of specific antibodies, primarily IgE antibodies, which then bind to the surface of mast cells.

   Upon subsequent exposure to the same allergen, these allergens bind to the IgE antibodies on the mast cell surface. This binding acts as a trigger, causing the mast cells to degranulate, meaning they release pre-formed chemical mediators stored in their granules into the surrounding tissues. One of the most significant of these mediators is histamine.

   Important

   Histamine is a potent vasoactive amine, meaning it has significant effects on blood vessels and other tissues. Its release is central to the immediate hypersensitivity reactions we commonly know as allergies.

   The release of histamine by mast cells initiates a cascade of events that manifest as the characteristic symptoms of an allergic reaction. These effects include:

   • Vasodilation: Histamine causes the small blood vessels (arterioles) to widen, increasing blood flow to the affected area. This leads to redness and warmth.
   • Increased Vascular Permeability: It makes the capillaries more permeable, allowing fluid and immune cells to leak out of the blood vessels and into the surrounding tissues. This leakage of fluid causes swelling (edema).
   • Contraction of Smooth Muscles: Histamine can cause the smooth muscles in various organs to contract. For instance, in the bronchi of the lungs, this leads to bronchoconstriction, making breathing difficult (a common symptom in asthma). In the gastrointestinal tract, it can lead to abdominal cramps and diarrhea.
   • Stimulation of Nerve Endings: Histamine can stimulate sensory nerve endings, leading to itching and pain.
   • Increased Mucus Secretion: In the respiratory tract, it can stimulate glands to produce more mucus, leading to a runny nose and congestion.

   Collectively, these actions of histamine are responsible for the diverse range of allergic symptoms, from mild reactions like sneezing, watery eyes, and skin rashes (hives) to severe, life-threatening reactions like anaphylaxis, which involves widespread vasodilation and bronchoconstriction.

   Considering the given options:

   • (A) Lowers blood pressure: While severe, systemic vasodilation caused by massive histamine release during anaphylaxis can lead to a dangerous drop in blood pressure, this is a consequence of its action rather than its primary "role" in causing general allergic symptoms. The broader role is mediating the symptoms themselves.
   • (B) Causes allergic symptoms: This option accurately and comprehensively describes the primary role of histamine released by mast cells. It directly mediates the redness, swelling, itching, bronchoconstriction, and other manifestations of an allergic reaction.
   • (C) Stimulates antibody formation: Antibodies are produced by B lymphocytes (plasma cells) in response to antigens. Histamine does not directly stimulate antibody formation.
   • (D) Destroys pathogens: Histamine is a chemical mediator involved in inflammation and allergic responses; it does not directly destroy pathogens. Pathogen destruction is primarily carried out by phagocytic cells (like macrophages and neutrophils) and cytotoxic lymphocytes.

   ✓Final answer

   The primary role of histamine released by mast cells is to cause the various symptoms associated with allergic reactions by inducing vasodilation, increasing vascular permeability, and contracting smooth muscles.

2. CBSE 2026Set ANNUAL1 mark
   Q.What is Allergy?

   ›Reveal solutionSolution

   Allergy is the immune system overreacting to substances (allergens) that are normally harmless, producing symptoms like sneezing, watery eyes, and breathing difficulty.

   Allergy refers to an exaggerated or hypersensitive response of the immune system to certain antigens present in the environment, called allergens — common examples include dust mites, pollen grains, animal dander, and certain foods.

   When an allergic individual is exposed to an allergen, plasma cells produce a class of antibody called IgE, which binds to mast cells in tissues. On re-exposure to the same allergen, this triggers the release of chemicals such as histamine and serotonin from mast cells, causing the typical symptoms of an allergic reaction — sneezing, watery eyes, running nose, and difficulty in breathing. Anti-histamine, adrenalin, and steroid drugs are commonly used to provide quick relief from these symptoms.

   ✓Final answer

   Allergy is an exaggerated/hypersensitive immune response of the body to certain harmless environmental antigens (allergens), such as dust, pollen, or certain foods.

3. CBSE 2026Set ANNUAL1 markMCQ
   Q.Allergy involves :

   (a) IgA

   (b) IgE

   (c) IgM

   (d) IgG

   ›Reveal solutionSolution

   Allergic reactions are driven by IgE antibodies, which sensitise mast cells/basophils so that on re-exposure to the allergen they release histamine and cause the symptoms of an allergic response.

   Of the five classes of human immunoglobulins (IgA, IgD, IgE, IgG and IgM), IgE is specifically responsible for mediating immediate (type I) hypersensitivity, or allergic, reactions. When an allergy-prone individual is first exposed to an allergen (such as dust mite protein, pollen or a particular food protein), plasma cells produce IgE antibodies specific to that allergen; these IgE molecules then bind, via their Fc region, to receptors on the surface of mast cells (in tissues) and basophils (in blood), effectively 'arming' or sensitising these cells. On a subsequent exposure to the same allergen, the allergen cross-links the allergen-specific IgE molecules already bound to the mast cell/basophil surface, triggering the cell to rapidly degranulate and release histamine and other inflammatory mediators, producing the classic allergic symptoms -- sneezing, watery eyes, bronchoconstriction/wheezing, itching, and in severe cases, anaphylaxis. IgG, IgA and IgM play other important roles in immunity (e.g., IgG is the major antibody in secondary immune responses, IgA guards mucosal surfaces, IgM is the first antibody produced), but IgE is the class specifically linked to allergy.

   ✓Final answer

   The correct option is b) IgE -- the antibody class responsible for mediating allergic (hypersensitivity) reactions.

4. CBSE 2025Set ANNUAL1 mark
   Q.Exaggerated response of the immune system to certain antigens present in the environment is called _____.

   ›Reveal solutionSolution

   An exaggerated, hypersensitive response of the immune system to certain otherwise harmless environmental antigens is called an allergy.

   The immune system normally protects the body by recognising and reacting to foreign antigens such as those on pathogens. In some individuals, however, the immune system over-reacts to certain substances present in the environment — such as dust, pollen grains, animal dander, or certain foods — which are otherwise harmless to most people. This exaggerated/hypersensitive response is called an allergy, and the substances that provoke it are called allergens. Common symptoms include sneezing, watery eyes, running nose and difficulty in breathing. This reaction is mediated mainly by an antibody class called IgE, which triggers mast cells to release chemicals such as histamine and serotonin that produce the allergic symptoms. Common anti-allergic drugs include anti-histamines, anti-serotonins and adrenaline, which give relief by countering the effects of the chemicals released during the allergic reaction.

   ✓Final answer

   Allergy — an exaggerated immune response to environmental antigens (allergens) such as dust or pollen.

5. CBSE 2024Set 57/1/11 markMCQ
   Q.In which of the following conditions/diseases is there a substantial increase in the activity of mast cells observed in the human body? (A) Typhoid (B) Allergy (C) Ascariasis (D) AIDS

   ›Reveal solutionSolution

   Mast cells are the primary effector cells of allergic reactions; their activity surges dramatically during an allergic response, making Allergy the correct answer.

   The core concept: mast cells are the body's "alarm cells" for immediate hypersensitivity.

   Mast cells reside in connective tissues, especially near blood vessels and mucosal surfaces. They are packed with granules containing histamine, heparin, and other inflammatory mediators. When an allergen (like pollen or dust) cross-links IgE antibodies bound to the mast cell surface, the cell degranulates explosively — releasing histamine and causing the classic symptoms of allergy: swelling, itching, redness, and bronchoconstriction. This is a type I hypersensitivity reaction.

   Now, let's examine each option against this function:

   1. Typhoid — Caused by Salmonella typhi bacteria. The immune response here is primarily cell-mediated (T-cells) and antibody-mediated (IgG, IgM). Macrophages and neutrophils are the key players. Mast cells are not substantially involved; their activity does not increase significantly.

   2. Allergy — This is the hallmark condition for mast cell activation. In an allergic individual, mast cells are sensitized by IgE antibodies specific to harmless environmental antigens. On re-exposure, the allergen binds to these surface IgE molecules, triggering rapid degranulation. This is the only condition among the options where mast cell activity is both substantial and diagnostic.

   3. Ascariasis — A helminthic infection caused by Ascaris lumbricoides. The immune response against large parasites involves eosinophils (which are recruited to attack the worm), Th2 cells, and IgE production. While mast cells can participate in anti-parasite responses, their increase is not substantial compared to the eosinophil-dominated reaction. The primary effector cells here are eosinophils, not mast cells.

   4. AIDS — Caused by HIV, which destroys CD4+ T-cells. The immune system is suppressed, not hyperactive. Mast cell activity is not increased; in fact, the overall immune function declines.

   Watch out

   A common mistake is to associate mast cells with any infection involving IgE. While IgE is elevated in both allergies and helminth infections, the substantial increase in mast cell activity is specific to allergic reactions. In ascariasis, the dominant cellular response is eosinophilic, not mastocytic.

   Tip

   Think of mast cells as the "fire alarm" of the immune system. In allergies, the alarm is triggered by a false alarm (pollen, dust). In parasitic infections, the alarm may ring, but the fire department (eosinophils) does the heavy work. Only in allergies does the alarm itself become the main problem.

   ✓Final answer

   The condition with a substantial increase in mast cell activity is Allergy, option (B).

6. CBSE 2024Set ANNUAL1 markMCQ
   Q.Which of the following is an antibody against allergy?

   (a) IgG

   (b) IgE

   (c) IgA

   (d) IgM

   ›Reveal solutionSolution

   IgE is the antibody isotype that mediates allergic (hypersensitivity) reactions by binding to mast cells/basophils and triggering histamine release on contact with an allergen.

   When an allergen (like pollen or dust mite protein) enters the body of a sensitised individual, plasma cells produce IgE antibodies, which bind to receptors on mast cells and basophils. On re-exposure, the allergen cross-links these IgE molecules, triggering degranulation and release of histamine and other mediators that cause the classic allergy symptoms (sneezing, watery eyes, rashes, and in severe cases, anaphylaxis). IgG is the main antibody in secondary immune responses, IgA is found in secretions (mucosal immunity), and IgM is the first antibody produced in a primary response - none of these is the allergy-associated antibody.

   ✓Final answer

   (b) IgE.

7. CBSE 2024Set ANNUAL1 markMCQ
   Q.Pollen grains of which plant cause allergy ?

   (a) Coriander

   (b) Parthenium

   (c) Triticum

   (d) None of these

   ›Reveal solutionSolution

   Parthenium pollen is a well-known cause of allergic reactions such as bronchial asthma and allergic rhinitis.

   Certain plant pollens, when inhaled, act as allergens and trigger allergic responses such as sneezing, watery eyes, wheezing and bronchial asthma in sensitive individuals. Parthenium (commonly called carrot grass or congress grass), an invasive weed introduced accidentally into India, produces large amounts of pollen that is a major cause of such respiratory allergies.

   ✓Final answer

   (b) Parthenium.

8. CBSE 2023Set 57/3/11 markMCQ
   Q.Assertion (A) : More and more children in metro cities of India suffer from allergies and asthma due to sensitivity to the environment. Reason (R) : Modern day lifestyle and a protected environment in early life has resulted in lowering the immunity.

   ›Reveal solutionSolution

   The assertion describes an observed health trend (rising allergies/asthma in urban children), while the reason offers a scientifically supported explanation (the "hygiene hypothesis"). Both statements are true, and the reason correctly explains the assertion.

   The Hygiene Hypothesis and Urban Health Trends

   The question asks you to evaluate two linked statements about childhood health in Indian cities. Understanding this requires familiarity with a well-established concept in immunology: the hygiene hypothesis.

   Our immune system develops through exposure. When young children encounter diverse microbes—bacteria, viruses, parasites—their immune systems learn to distinguish real threats from harmless substances. In overly sanitized environments, this training is incomplete. The immune system, lacking proper "education," begins overreacting to benign triggers like pollen, dust mites, or pet dander. This misdirected response manifests as allergies and asthma.

   Metro cities in India present a perfect storm: air pollution, enclosed air-conditioned spaces, reduced outdoor play, excessive use of antibacterial products, and smaller family sizes (fewer infections shared among siblings). Children grow up in what immunologists call a "protected environment"—paradoxically making them more vulnerable.

   Evaluating Each Statement

   1. Assertion (A) is factually correct.

      Epidemiological data from Indian metros (Delhi, Mumbai, Bangalore) show a documented rise in childhood allergic rhinitis, asthma, and atopic dermatitis over the past two decades. The prevalence has increased from roughly 10–15% to 20–30% in urban populations, while rural rates remain lower. This is an observed, measurable trend.

   2. Reason (R) is also correct.

      Modern lifestyle factors—smaller living spaces, reduced microbial exposure, dietary changes, increased antibiotic use—have been shown to suppress early immune system development. The "protected environment" mentioned is not protective in a beneficial sense; it deprives the immune system of the challenges it needs to mature properly. This lowering of immunity is more accurately described as immune dysregulation: the system becomes hyperactive against the wrong targets.

   3. Does (R) explain (A)?

      Yes. The hygiene hypothesis directly accounts for why urban children, living in sanitized, less microbially diverse environments, develop more allergies and asthma. The reason provides the mechanistic explanation for the assertion. Rural children, exposed to farms, animals, and soil microbes, show lower rates—supporting the causal link.

   Tip

   In assertion-reason questions, check three things in order: Is A true? Is R true? Does R actually cause or explain A (not just coincide with it)?

   Watch out

   "Lowering immunity" might sound like children are more prone to infections, but the hygiene hypothesis describes skewed immunity—overreaction to allergens, not general weakness. The immune system is active, just misdirected.

   ✓Final answer

   Both the assertion and the reason are true, and the reason correctly explains the assertion. The answer is (A) if options follow the standard format: "Both A and R are true, and R is the correct explanation of A."

9. CBSE 2023Set ANNUAL1 mark
   Q.State the main cause of allergy.

   ›Reveal solutionSolution

   Allergy results from the immune system over-reacting to normally harmless environmental substances (allergens).

   Allergy is an exaggerated or hypersensitive response of the immune system to certain antigens present in the environment, called allergens — common examples include dust, pollen grains, animal dander and mites. On first exposure, the immune system produces IgE-type antibodies specific to the allergen; these antibodies bind to mast cells and basophils. On re-exposure to the same allergen, it cross-links these bound IgE antibodies, causing the mast cells to degranulate and release chemical mediators such as histamine and serotonin. These mediators are responsible for the typical symptoms of allergy — sneezing, watery eyes, running nose, and difficulty in breathing (as in asthma).

   ✓Final answer

   An exaggerated immune (IgE-mediated, histamine-releasing) response to normally harmless environmental allergens.

10. CBSE 2023Set ANNUAL1 markMCQ
    Q.Allergy involves :

    (a) IgA

    (b) IgE

    (c) IgM

    (d) IgG

    ›Reveal solutionSolution

    Allergic (immediate hypersensitivity) reactions are mediated by IgE antibodies.

    When an allergen (like pollen or dust) first enters a sensitive individual, B cells produce IgE antibodies specific to that allergen; these IgE molecules bind to receptors on mast cells and basophils. On subsequent exposure to the same allergen, cross-linking of bound IgE triggers degranulation of these cells, releasing histamine and other inflammatory mediators that cause the classic allergy symptoms (sneezing, watery eyes, breathlessness). Option (a) IgA is the main antibody found in secretions (saliva, tears, mucus) providing mucosal defence, not typically the allergy mediator. Option (c) IgM is the first antibody produced in a primary immune response and is important in early defence and agglutination reactions. Option (d) IgG is the most abundant antibody in blood, crucial for long-term immunity and the only antibody that crosses the placenta, but it is not the class responsible for classic allergic hypersensitivity.

    ✓Final answer

    The correct option is b) IgE.

11. CBSE 2021Set D1 markMCQ
    Q.Chemical released due to allergy is

    (a) Histamine

    (b) Serotonin

    (c) Both (A) and (B)

    (d) None of these

    ›Reveal solutionSolution

    During an allergic reaction, mast cells release histamine and serotonin, so the answer is (C) Both (A) and (B).

    Allergy is the exaggerated response of the immune system to certain antigens (allergens) present in the environment. On exposure to an allergen, IgE antibodies bind to mast cells, causing them to release chemical mediators.

    The chief chemicals released are histamine and serotonin, which produce the symptoms of allergy — sneezing, watery eyes, running nose and difficulty in breathing. Since both chemicals are released, both options are correct.

    ✓Final answer

    (C) Both (A) and (B).

12. CBSE 2019Set 57/4/11 mark
    Q.State the functions of mast cells in allergy response.

    (OR)

    State the function of interpherons.

    ›Reveal solutionSolution

    Part (a): Mast cells release histamine and other mediators when an allergen binds their surface IgE, producing the immediate symptoms of allergy. Part (b): Interferons are proteins from virus-infected cells that make neighbouring healthy cells resistant to the virus, checking its spread.

    Part (a)

    Mast cells are granule-containing immune cells present in tissues, especially near blood vessels and mucosal surfaces. Their surface is coated with IgE antibodies specific to an allergen. When that allergen enters the body and cross-links the IgE, the mast cells are activated and undergo degranulation, releasing chemical mediators — chiefly histamine and serotonin. These mediators cause vasodilation, increased capillary permeability and smooth-muscle contraction, giving the familiar allergic response: sneezing, running nose, watery eyes, itching, swelling and difficulty in breathing (as in asthma).

    ✓Final answer

    In allergy, mast cells respond to allergen-bound IgE by releasing histamine and other mediators, which produce the immediate hypersensitivity (allergic) symptoms.

    Part (b)

    Interferons are a group of protective (antiviral) proteins, a type of cytokine, secreted by cells that have been infected by a virus. They form part of the body's innate (non-specific) defence. The interferon released by an infected cell diffuses to surrounding uninfected cells and stimulates them to synthesise substances that block viral replication, so these cells become resistant to the virus. This limits the spread of infection; interferons also enhance the activity of other immune cells such as macrophages and NK cells.

    ✓Final answer

    Interferons secreted by virus-infected cells protect neighbouring healthy cells from viral infection, checking the spread of the virus as part of innate immunity.