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Answer the following (group 3) · Q3

Q.How will you illustrate the principle, minimization of steps?

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Step 1. Recall the principle (Section 16.3.8). Reduce Derivatives asks chemists to minimise or avoid unnecessary derivatisation, such as installing/removing protecting groups, since each such step needs additional reagents and generates additional waste, and also lowers atom economy.

Step 2. Walk through the worked illustration. Starting from m-hydroxybenzaldehyde (which has both a -CHO group and a free -OH group), the -OH group is first protected using C6H5CH2Cl (converting -OH to -OCH2C6H5). The -CHO group is then oxidised to -COOH using an oxidising agent [O], while the protected -OH group is left untouched. Finally, the protecting group is removed again (deprotection of the OH group), regenerating the free -OH group alongside the new -COOH group, giving the target product, m-hydroxybenzoic acid. …

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