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Question 64 of 65

Q.α\alpha-D(+) Glucose and β\beta-D(+) Glucose are :

(a) Enantiomers
(b) Epimers
(c) Conformational isomers
(d) Anomers
Puducherry TnboardTamil Nadu HSC (DGE) Board 2026MCQ· 1mImportance★★★★★
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When glucose cyclises to its ring (pyranose/furanose) form, a new stereocentre is created at C-1; the two possible configurations at just this one carbon give rise to α\alpha- and β\beta-D-glucose, a relationship specifically called anomerism.

When the open-chain form of D-glucose cyclises (the −OH-OH at C-5 attacking the aldehyde carbon, C-1), a new asymmetric (stereogenic) carbon is created at C-1, called the anomeric carbon. Depending on the spatial orientation of the newly formed −OH-OH group at this carbon (relative to the reference −CH2OH-CH_2OH group at C-5), two distinct cyclic forms result: α\alpha-D(+)-glucose (with the C-1 −OH-OH on the opposite side to the reference group) and β\beta-D(+)-glucose (same side). Since these two forms differ in configuration at only this one carbon (the anomeric carbon) while all other stereocentres remain identical, they are called anomers — a special sub-class of diastereomers (epimers differ at any single stereocentre in general, b …

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