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Neurological Disorders · Q40

Q.What is Alzheimer's disease? Name one structural change seen in the brain of an affected individual and state its common symptoms.

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Alzheimer's disease is a progressive degenerative brain disorder, mainly affecting older individuals, associated with the abnormal build-up of two kinds of protein deposits within brain tissue — amyloid plaques accumulating between neurons and neurofibrillary tangles forming within neurons — which disrupt normal neuron function and eventually cause widespread loss of neurons, particularly in regions important for memory such as the hippocampus. Common symptoms include progressive memory loss (especially of recent events in the earlier stages), increasing confusion and disorientation, changes in mood and behaviou …

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