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Neurological Disorders · Q41

Q.Differentiate between Parkinson's disease and Alzheimer's disease on the basis of the primary symptoms observed and the brain region primarily affected.

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Parkinson's disease is best understood as primarily a movement disorder: it arises from the loss of dopamine-producing neurons in a fairly localised region of the midbrain (the substantia nigra), and its main symptoms — tremor, rigidity, slowness of movement, postural instability — are all motor in nature. Alzheimer's disease is best understood as primarily a memory and cognitive disorder: it arises from a more widespread accumulation of abnormal proteins (amyloid plaques and neurofibrillary tangles) and neuron loss across the cerebral cortex and hippocampus, and its main symptoms — progressive memory loss, confusion, impaired reasoning and language — are all cognitive in nature. Both are progressive and currently in …

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