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Q.According to the Hardy-Weinberg principle, the allele frequency of a population remains constant. How do you interpret the change of frequency of alleles in a population ?

(OR)
Coelacanth was caught in South Africa. State the significance of discovery of Coelacanth in the evolutionary history of vertebrates.
CBSECBSE Class XII Board 2019Subjective· 1mImportance★★★★★
✓ Free question

Part (a): Allele frequencies stay constant only in the absence of evolutionary forces, so any observed change in allele frequency means the Hardy–Weinberg equilibrium is disturbed and the population is evolving (by mutation, gene flow, drift, non-random mating or natural selection). Part (b): The living coelacanth is a lobe-finned fish and a connecting link/living fossil, evidence that tetrapods evolved from such fishes.

The Hardy–Weinberg principle says that in an idealised population the allele (gene) frequencies remain constant from generation to generation — the population is in genetic equilibrium. This holds only when five conditions are met: no mutation, no gene flow (migration), random mating, a very large population (no genetic drift), and no natural selection. The principle is a null model: it describes a population that is not evolving.

Hence, when we actually observe allele frequencies changing in a population, we interpret it as a sign that at least one of these conditions has been violated — the genetic equilibrium is disturbed and evolution is taking place. The disturbing factors are the agents of evolution:

  • Gene mutations introduce new alleles.
  • Gene flow / genetic recombination through migration adds or removes alleles.
  • Genetic drift randomly changes frequencies, especially in small populations (founder effect).
  • Natural selection favours advantageous alleles, raising their frequency.
  • Non-random mating alters genotype proportions.
✓Final answer

A change in allele frequency indicates that the Hardy–Weinberg equilibrium has broken down and the population is evolving, driven by natural selection, mutation, genetic drift, gene flow or non-random mating.

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