Q.Explain the induced fit model for mode of enzyme action.

Step 1. The induced fit model was proposed by Koshland in 1959 as a more accurate alternative to the rigid lock-and-key model.

Step 2. It states that the approach of the substrate to the enzyme induces a conformational change in the enzyme's shape, rather than the enzyme's active site being a pre-formed, rigid fit.

Step 3. The active site is treated as flexible: it continually reshapes itself through its interactions with the substrate, right up until the substrate is completely bound. …

Explain Koshland's induced-fit theory, contrasting it with the ri …

• Describing the induced fit model as if the active site were rigid (that description belongs to the lock-and-key model, which induced fit was proposed to replace). …