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Question 53 of 66

Q.Complete the chart showing human proteins produced by rDNA technology to treat human diseases and re-write.
Disorders/diseases | Recombinant Proteins
? | Erythropoietin
Asthma | ?
? | Tissue plasminogen activator
Emphysema | ?

Maharashtra MsbshseMaharashtra HSC (MSBSHSE) Board 2023Subjective· 2mImportance★★★★★
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Several recombinant human proteins produced by rDNA technology are used to treat specific disorders: erythropoietin for anaemia, DNase for asthma/respiratory mucus disorders, tPA for heart attack (clot dissolution), and alpha-1 antitrypsin for emphysema.

Recombinant DNA technology allows human genes to be cloned into bacteria, yeast or other host cells to mass-produce therapeutic human proteins. The completed chart reads:

Anaemia | Erythropoietin - stimulates red blood cell production in the bone marrow, used to treat anaemia especially in patients with chronic kidney disease.

Asthma | DNase (deoxyribonuclease) - an enzyme that breaks down the thick, DNA-rich mucus in the airways, easing breathing in obstructive respiratory conditions.

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