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Question 57 of 74

Q.Vaccine is not produced against Chickenpox. Why ?

Tamil Nadu DgeTamil Nadu HSC (DGE) Board 2023Subjective· 2mImportance★★★★★
77% · 57/74 Questions
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A chickenpox (varicella) vaccine does exist and is in real-world use — the question's premise is outdated; the biological point it may be probing is that VZV, like other herpesviruses, can go latent and reactivate.

Chickenpox is caused by the Varicella-zoster virus (VZV). A live-attenuated varicella vaccine (developed in the 1970s–80s and licensed for use from the 1990s onward) is genuinely available and included in the immunisation schedules of several countries, so it would not be correct to say categorically that no vaccine exists against chickenpox. If the question is instead probing why some viral diseases are historically hard to vaccinate against completely, the relevant biology is: VZV, being a herpesvirus, can establish lifelong latency in sensory nerve ganglia (such as the dorsal root ganglia) after the primary (chickenpox) infection, and can later reactivate — often years afterwards, especially when immunity wanes — causing herpes zoster (shingles). This ability to hide from the immune system in a latent, non-replicating state inside nerve cells is a general reason some viruses are difficult to eliminate by vaccination alone, since a vaccine that prevents the primary infection does not necessar …

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