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Biology · Ch 4 — Molecular Basis of Inheritance

Protein Synthesis

4.5

Protein Synthesis

Proteins act as structural components, enzymes and hormones, and cells must continually synthesise new ones. This overall process of protein synthesis has two stages: transcription, the copying of genetic information from a template strand of DNA into a single-stranded RNA transcript (with adenine pairing with uracil instead of thymine), and translation, the decoding of that RNA message into a polypeptide chain.

Central Dogma : A double-stranded DNA molecule gives rise to mRNA, which acts as the messenger that programmes the synthesis of a polypeptide chain (protein). This unidirectional flow of information from DNA to RNA to protein is the central dogma of molecular biology, postulated by F.H.C. Crick in 1958:

DNA → (Transcription) → mRNA → (Translation) → Polypeptide …