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Q.What is aneuploidy ? Explain its types.

Puducherry TnboardTamil Nadu HSC (DGE) Board 2016Subjective· 5mImportance★★★★★
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Aneuploidy is an abnormal chromosome count differing from 2n by one or a few chromosomes, usually from non-disjunction.

Aneuploidy is a chromosomal aberration in which the chromosome number deviates from the normal diploid (2n) complement by the addition or loss of one or a few (but not a complete haploid set of) chromosomes. It usually arises from non-disjunction -- the failure of homologous chromosomes (in meiosis I) or sister chromatids (in meiosis II or mitosis) to separate properly, so one gamete/daughter cell gets an extra chromosome and another gets one fewer.

Types:

  1. Monosomy (2n-1) -- one member of a homologous pair is missing, so that chromosome is present in a single copy.
  2. Nullisomy (2n-2) -- both members of a homologous pair are missing, so that chromosome type is entirely absent.
  3. Trisomy (2n+1) -- one extra chromosome is added to a pair, making that particular chromosome present in three copies (e.g. trisomics studied extensively in Datura by A.F. Blakeslee). …

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